Interleukin-6 gene −174G>C and −636G>C promoter polymorphisms and prostate cancer risk

Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes, IL - 6 polymorphisms may modulate PCa risk. IL - 6 −174 G>C (rs 1800795, also designated −236 G>C) an...

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Published in:Molecular biology reports 2013, Vol.40 (1), p.449-455
Main Authors: Magalhães, J. F., Cortinhas, A. J., Albuquerque, C. M., Baptista, C. S., Ribeiro, R., Viegas, Carlos, Matos, Augusto, Machado, João, Pires, Maria A., Guedes-Pinto, Henrique, Martins-Bessa, A., Leitão, J. C., Bastos, E.
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Case-Control Studies
Genetic markers
Genetic Predisposition to Disease
Histology
Humans
Interleukin-6 - genetics
Life Sciences
Male
Morphology
Polymorphism
Polymorphism, Single Nucleotide
Population Groups - genetics
Promoter Regions, Genetic
Prostate cancer
Prostatic Neoplasms - genetics
Publication Bias
Risk factors
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Summary:Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes, IL - 6 polymorphisms may modulate PCa risk. IL - 6 −174 G>C (rs 1800795, also designated −236 G>C) and −636 G>C (rs 1800796, also designated −572 G>C) promoter polymorphisms have been implicated in PCa susceptibility, albeit still controversial. A literature search using PubMed and Highwire databases was conducted, resulting in eight case–control studies concerning the IL - 6 −174 G>C polymorphism (11,613 PCa cases and 13,992 controls) and four case–control publications regarding the IL - 6 −636 G>C polymorphism (1,941 PCa cases and 3,357 controls). In order to derive a more precise estimation, a meta-analysis based upon these selected case–control studies was performed. There was no significant association between IL - 6 −174 G>C polymorphism and PCa increased risk. Nevertheless, the presence of allele C and the CC genotype were statistically significantly associated with decreased PCa risk in the overall analysis for IL - 6 −636 G>C polymorphism. Additional studies in larger samples and analyses of functional repercussions of these SNPs in prostate tumor cells are necessary to validate these findings.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-012-2079-9