Downward trend in the prevalence of hospitalisation for atherothrombotic disease

• Published in: International journal of cardiology 2013-04, Vol.164 (2), p.185-192
• Main Authors: Briffa, Thomas G, Nedkoff, Lee, Knuiman, Matthew, Norman, Paul E, Hung, Joseph, Hankey, Graeme J, Thompson, Peter L, Geelhoed, Elizabeth, Hickling, Siobhan, Sanfilippo, Frank, Bremner, Alexandra, Hobbs, Michael
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Atherosclerosis (general aspects, experimental research); Atherosclerosis - diagnosis; Atherosclerosis - epidemiology; Atherosclerosis - therapy; Atherothrombotic disease; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular; Chronic kidney disease; Cross-Sectional Studies; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Hospitalization - trends; Humans; Kidneys; Longitudinal Studies; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Prevalence; Renal failure; Thrombosis - diagnosis; Thrombosis - epidemiology; Thrombosis - therapy; Trends; Urinary system involvement in other diseases. Miscellaneous; Western Australia - epidemiology
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2011.06.122

Abstract Background The prevalence of hospitalised atherothrombotic disease affecting the coronary, cerebrovascular and peripheral vasculature is expected to increase due to improving survival, ageing and changing risk factor profiles. This study determined sex, age-standardised and age-specific (35–54, 55–69, 70–84 years) prevalence of atherothrombotic disease and its association with diabetes and chronic kidney disease in Western Australian residents from 2000 to 2007. Methods In a cross-sectional and longitudinal study, person-linked hospitalisations for atherothrombotic disease were obtained using records from 1985. From 2000 to 2007, total and vasculature-specific prevalence of atherothrombotic disease (as a principal diagnosis) was calculated using a 15-year lead-in to determine prior disease and comorbidity. Results In 2007, 45,916 (8.6%) men and 22,782 (4.3%) women in Western Australia had established atherothrombotic disease and about 25% had diabetes, 10% had chronic kidney disease, and 5% had both. From 2000 to 2007 the estimated average annual change in age-standardised atherothrombotic disease prevalence was − 0.6%/year (95% CI − 0.8, −0.4) in men and − 0.7%/year (95% CI − 1.0, −0.4) in women. Similar modest declines were seen in age-standardised prevalence of monovascular and polyvascular atherothrombotic disease. The proportion of cases with diabetes increased by about 5%/year, the proportion having chronic kidney disease increased slowly in women (1.5%/year) and was stable in men, and the proportion with both comorbidities increased at about 9%/year. Conclusion The age-standardised prevalence of atherothrombotic disease requiring hospitalisation has been in marginal decline in Western Australia this decade, despite the proportion of affected persons with diabetes and/or chronic kidney disease steadily rising.