Cadmium exposure and the risk of breast cancer in Japanese women

Non-occupational exposure to cadmium has been suspected to be a risk factor for breast cancer. The present study examined the association between urinary cadmium level and the risk of breast cancer in a case–control study among Japanese women. Cases were 153 women newly diagnosed and histologically...

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Bibliographic Details
Published in:Breast cancer research and treatment 2013-02, Vol.138 (1), p.235-239
Main Authors: Nagata, Chisato, Nagao, Yasuko, Nakamura, Kozue, Wada, Keiko, Tamai, Yuya, Tsuji, Michiko, Yamamoto, Satoru, Kashiki, Yoshitomo
Format: Article
Language:English
Subjects:
Adult
Age
Asian Continental Ancestry Group
Biological and medical sciences
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - etiology
Cadmium
Cadmium - adverse effects
Cadmium - urine
Cancer
Cancer research
Case-Control Studies
Diagnosis
Environmental Exposure
Epidemiology
Female
Females
Gynecology. Andrology. Obstetrics
Hospitals
Human exposure
Humans
Japan - epidemiology
Mammary gland diseases
Medical sciences
Medicine
Medicine & Public Health
Menopause
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Odds Ratio
Oncology
Risk
Risk factors
Surgery
Tumors
Urine
Women
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Summary:Non-occupational exposure to cadmium has been suspected to be a risk factor for breast cancer. The present study examined the association between urinary cadmium level and the risk of breast cancer in a case–control study among Japanese women. Cases were 153 women newly diagnosed and histologically confirmed with breast cancer at a general hospital in Gifu, Japan. A total of 431 controls individually matched to cases by age, menopausal status, and the period of urine sampling were selected from those who attended a breast cancer mass screening at this hospital. Urinary cadmium levels were measured using spot urine samples. Spot urine samples were collected from cases after surgery but before any cancer therapy. For controls, spot urine samples were obtained at the date of the screening visit. Information on known or suggested breast cancer risk factors was obtained by a self-administered questionnaire. The odds ratios (ORs) and 95 % confidence intervals (CIs) of breast cancer according to the tertile of the creatinine-adjusted cadmium level were calculated using conditional logistic regression models. Women in the highest tertile of the creatinine-adjusted cadmium level (>2.620 μg/g) had significantly elevated OR of breast cancer relative to those in the lowest tertile (
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-013-2414-4