High rates of multidrug resistance in Enterococcus faecalis and E. faecium isolated from inpatients and outpatients in Taiwan

Abstract Longitudinal national data on resistance in Enterococcus faecalis and E. faecium from different sources in Taiwan are rare. The present study analyzed data from the Taiwan Surveillance of Antimicrobial Resistance program to address this issue. Between 2002 and 2010, a total of 1696 E. faeca...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2013-04, Vol.75 (4), p.406-411
Main Authors: Wang, Jann-Tay, Chang, Shan-Chwen, Wang, Hui-Yin, Chen, Pei-Chen, Shiau, Yih-Ru, Lauderdale, Tsai-Ling
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology
Antimicrobial resistance
Child
Child, Preschool
Drug Resistance, Multiple, Bacterial
Enterococcus faecalis
Enterococcus faecalis - drug effects
Enterococcus faecalis - isolation & purification
Enterococcus faecium
Enterococcus faecium - drug effects
Enterococcus faecium - isolation & purification
Female
Gram-Positive Bacterial Infections - epidemiology
Gram-Positive Bacterial Infections - microbiology
Humans
Infectious Disease
Inpatients
Internal Medicine
Male
Microbial Sensitivity Tests
Middle Aged
Multidrug resistance
Outpatients
Prevalence
Taiwan - epidemiology
Vancomycin-resistant enterococci
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Summary:Abstract Longitudinal national data on resistance in Enterococcus faecalis and E. faecium from different sources in Taiwan are rare. The present study analyzed data from the Taiwan Surveillance of Antimicrobial Resistance program to address this issue. Between 2002 and 2010, a total of 1696 E. faecalis and 452 E. faecium isolates were studied. Although these 2 species together comprised similar percentages of all enterococci in each study year (94.1–97.2%, P = 0.19), the proportion of E. faecium increased from 12.4% in 2002 to 27.3% in 2010 ( P < 0.001). The most noteworthy change in susceptibilities of these 2 species was vancomycin resistance in E. faecium (VREfm), which increased from 0.3% in 2004 to 24.9% in 2010 ( P < 0.001). VREfm prevalence differed significantly between geographic regions, patient age groups, and locations. Multidrug resistance was very common in both species even in isolates from outpatients (82.7% for E. faecalis and 98.1% for E. faecium ), at rates similar to those from intensive care unit (ICU) and non-ICU patients (80.5–80.9% in E. faecalis and 97.2–98.6% in E. faecium ). Nonsusceptibility to linezolid was
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2013.01.004