Relation of chemokines to BMI and insulin resistance at ages 18–21

• Published in: International Journal of Obesity 2013-03, Vol.37 (3), p.420-423
• Main Authors: Ognjanovic, S, Jacobs, D R, Steinberger, J, Moran, A, Sinaiko, A R
• Format: Article
• Language: English
• Subjects: 631/443/592; 631/45/127/98; 692/699/1702/393; Adipokines - blood; Adipose tissue; Adolescent; Adolescents; Biological and medical sciences; Biomarkers - blood; Blood Glucose - metabolism; Blood Pressure; Body fat; Body Mass Index; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Chemokine CCL4 - blood; Chemokines; Chemokines - blood; Children; Chronic illnesses; Cross-Sectional Studies; Cytokines; Epidemiology; Female; Genetic aspects; Glucose; Glucose Clamp Technique; Health aspects; Health Promotion and Disease Prevention; Humans; Inflammation - blood; Insulin Resistance; Interleukin-6 - blood; Interleukin-8 - blood; Internal Medicine; Leukocytes; Lipids; Lipids - blood; Male; Measurement; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Neutrophils; Nicotinamide Phosphoribosyltransferase - blood; Obesity; Obesity - blood; Obesity - complications; Obesity - epidemiology; original-article; Pediatrics; Physiological aspects; Production increases; Proteins; Public Health; Risk Factors; Teenagers; Tumor Necrosis Factor-alpha - blood; United States - epidemiology; Weight control; Young Adult; Young adults
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/ijo.2012.61

Objective: In obesity, adipose tissue becomes a significant source of chemokines and inflammatory cytokines that are associated with chronic systemic low-grade inflammation and may lead to insulin resistance. Studies in children have mainly focused on inflammatory cytokines and there are limited data for chemokines in adolescents and young adults. We studied the relation of chemokines to cardiovascular (CV)-risk factors, insulin resistance and adipocytokines in 18–21-year-old individuals. Subjects and Design: Cross-sectional data collected in a cohort originally enrolled at mean age 13, with data for the present study obtained from 252 examined at age 18.7±0.1 years. Methods: Multiple linear regression models were used to analyze the associations among chemokines (monocyte chemotactic protein-1, macrophage inflammatory protein-1β (MIP-1β), visfatin and interleukin-8 (IL-8)) and between chemokines and body mass index (BMI), glucose, lipids, blood pressure (BP), insulin resistance (euglycemic hyperinsulinemic clamp) and adipocytokines (IL-6, TNF-α and adiponectin). Results: Chemokine levels were significantly intercorrelated. Significant associations ( P