Association of pituitary tumor transforming gene expression with early oral tumorigenesis and malignant progression of precancerous lesions

Background. Pituitary tumor transforming gene (PTTG1) is overexpressed in many types of human cancers and is involved in late‐stage tumor progression. The role of PTTG1 in initiating tumorigenesis is unclear. Methods. PTTG1 expression was assessed in precancerous lesions and squamous cell carcinomas...

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Published in:Head & neck 2011-05, Vol.33 (5), p.719-726
Main Authors: Liao, Li-Jen, Hsu, Yi-Hsin, Yu, Chuan-Hang, Chiang, Chun-Pin, Jhan, Jing-Ru, Chang, Lien-Cheng, Lin, Jing-Jer, Lou, Pei-Jen
Format: Article
Language:English
Subjects:
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Areca - adverse effects
arecolin
Biomarkers, Tumor - metabolism
Brain tumors
Carcinogens
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Transformation, Neoplastic - metabolism
Epithelial Cells - metabolism
Epithelial Cells - pathology
Gene expression
Head
Humans
Mouth Mucosa - metabolism
Mouth Mucosa - pathology
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Neck
Neoplasm Proteins - metabolism
oral cancer
Oral cavity
p53
Pituitary tumor-transforming proteins
Polymerase Chain Reaction
Precancerous Conditions - metabolism
Prognosis
PTTG1
Retrospective Studies
Securin
Smoking - adverse effects
Smoking - epidemiology
squamous cell carcinoma
Taiwan - epidemiology
Tumorigenesis
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Summary:Background. Pituitary tumor transforming gene (PTTG1) is overexpressed in many types of human cancers and is involved in late‐stage tumor progression. The role of PTTG1 in initiating tumorigenesis is unclear. Methods. PTTG1 expression was assessed in precancerous lesions and squamous cell carcinomas of the oral cavity (OSCC). The association between the protein expression and clinicopathologic parameters was analyzed. The expression level of PTTG1 upon carcinogen treatment was also investigated. Results. PTTG1 was overexpressed in both precancerous lesions and OSCC. The expression of PTTG1 was associated with carcinogen exposure in vivo and in vitro. PTTG1 overexpression was an independent factor for oral cancer development in precancerous lesions. Conclusions. This study provides the first evidence that PTTG1 is involved in the early stages of oral tumorigenesis. Carcinogen exposure may cause the initial induction of PTTG1 expression in oral precancerous lesions. PTTG1 overexpression is a potential prognosticator for malignant progression of oral precancerous lesions. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
ISSN:1043-3074
1097-0347
1097-0347
DOI:10.1002/hed.21531