Loading…
Surveillance of lymphatic filariasis after stopping ten years of mass drug administration in rural communities in south India
Background While various studies provided insight into the impact of mass drug administration (MDA), information on the dynamics of the post-MDA threshold level lymphatic filariasis (LF) infection facilitates understanding its disappearance pattern and determining the duration of post-MDA monitoring...
Saved in:
| Published in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2013-05, Vol.107 (5), p.293-300 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c356t-45dadbb8c4875fe25292ca25400ccd7f99315cfb22059b7ed578cfeb47b85e393 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c356t-45dadbb8c4875fe25292ca25400ccd7f99315cfb22059b7ed578cfeb47b85e393 |
| container_end_page | 300 |
| container_issue | 5 |
| container_start_page | 293 |
| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| container_volume | 107 |
| creator | Ramaiah, K.D. Vanamail, P. |
| description | Background
While various studies provided insight into the impact of mass drug administration (MDA), information on the dynamics of the post-MDA threshold level lymphatic filariasis (LF) infection facilitates understanding its disappearance pattern and determining the duration of post-MDA monitoring and evaluation.
Methods
The changes in microfilaraemia (Mf) prevalence and vector infection rates were monitored for four (2005-2008) and six years (2005-2010) respectively after stopping ten rounds of annual mass diethylcarbamazine (DEC) administration in a group of five villages located in South India. Four years after stopping MDA, circulating filarial antigenaemia (Ag) status among children and adults was also assessed in two villages.
Results
Overall Mf prevalence (n = 700) and vector infection rates (n=803-3520) showed a declining trend. Two villages maintained zero Mf status in each of the four years, vector infection rate was zero from the third year onwards and Ag prevalence in adults was 0.4% (n = 226). In two other villages despite persistence of Mf and vector infection there was zero vector infectivity rate during the third to sixth year and Ag prevalence among children (n = 50) was nil. In the fifth village Mf prevailed at |
| doi_str_mv | 10.1093/trstmh/trt011 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1327728849</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/trstmh/trt011</oup_id><sourcerecordid>1327728849</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-45dadbb8c4875fe25292ca25400ccd7f99315cfb22059b7ed578cfeb47b85e393</originalsourceid><addsrcrecordid>eNqFkTtP5DAQgK0T6FjgymuRGySacH7E2CkRggMJiQKoI8exWaM4Dh4baQv--yXaPSipRhp98_oGod-UnFPS8D85QQ7rOWRC6Q-0okqqigvC99CKEC6qhhF-gA4BXglhgormJzpgvK6ZkGyFPh5Lerd-GPRoLI4OD5swrXX2Bjs_6OQ1eMDaZZsw5DhNfnzB2Y54Y3WCpSBoANyn8oJ1H_zoIae5PI7YjziVpAdsYghl9NlbWJIQS17ju7H3-hjtOz2A_bWLR-j55vrp6ra6f_h7d3V5XxkuLnJVi173XadMraRwlgnWMKOZqAkxppeuaTgVxnWMEdF00vZCKuNsV8tOCcsbfoTOtn2nFN-KhdwGD8YuV9tYoKWcScmUqhe02qImRYBkXTslH3TatJS0i_F2a7zdGp_5k13r0gXbf9L_Fc_A6Q7QYPTg0mzawxcnmVR0_tHnjrFM38z8B6fGnN0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1327728849</pqid></control><display><type>article</type><title>Surveillance of lymphatic filariasis after stopping ten years of mass drug administration in rural communities in south India</title><source>Oxford Journals Online</source><creator>Ramaiah, K.D. ; Vanamail, P.</creator><creatorcontrib>Ramaiah, K.D. ; Vanamail, P.</creatorcontrib><description>Background
While various studies provided insight into the impact of mass drug administration (MDA), information on the dynamics of the post-MDA threshold level lymphatic filariasis (LF) infection facilitates understanding its disappearance pattern and determining the duration of post-MDA monitoring and evaluation.
Methods
The changes in microfilaraemia (Mf) prevalence and vector infection rates were monitored for four (2005-2008) and six years (2005-2010) respectively after stopping ten rounds of annual mass diethylcarbamazine (DEC) administration in a group of five villages located in South India. Four years after stopping MDA, circulating filarial antigenaemia (Ag) status among children and adults was also assessed in two villages.
Results
Overall Mf prevalence (n = 700) and vector infection rates (n=803-3520) showed a declining trend. Two villages maintained zero Mf status in each of the four years, vector infection rate was zero from the third year onwards and Ag prevalence in adults was 0.4% (n = 226). In two other villages despite persistence of Mf and vector infection there was zero vector infectivity rate during the third to sixth year and Ag prevalence among children (n = 50) was nil. In the fifth village Mf prevailed at <1.0% and Ag prevalence among 1-7 year old children was 4.6% (n = 44) and vector infectivity rate during the sixth year was 0.1% (n = 852).
Conclusion
The incidence of sporadic new infections is evident in highly endemic communities such as the fifth village. However, there is uncertainty on the potential of the Ag positive children to reestablish infection. Six years of post-MDA monitoring and evaluation appears to be adequate to discern the status of transmission interruption and appropriate decision making.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1093/trstmh/trt011</identifier><identifier>PMID: 23442572</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Animals ; Biological and medical sciences ; Child ; Child, Preschool ; Diseases caused by nematodes ; Drug Administration Schedule ; Drug Monitoring ; Elephantiasis, Filarial - epidemiology ; Elephantiasis, Filarial - immunology ; Elephantiasis, Filarial - transmission ; Female ; Filariases ; General aspects ; Helminthic diseases ; Humans ; India - epidemiology ; Infant ; Infectious diseases ; Lymphatic filariases ; Male ; Medical sciences ; Middle Aged ; Parasitic diseases ; Rural Population ; Young Adult</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 2013-05, Vol.107 (5), p.293-300</ispartof><rights>Royal Society of Tropical Medicine and Hygiene 2013. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-45dadbb8c4875fe25292ca25400ccd7f99315cfb22059b7ed578cfeb47b85e393</citedby><cites>FETCH-LOGICAL-c356t-45dadbb8c4875fe25292ca25400ccd7f99315cfb22059b7ed578cfeb47b85e393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27278120$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23442572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramaiah, K.D.</creatorcontrib><creatorcontrib>Vanamail, P.</creatorcontrib><title>Surveillance of lymphatic filariasis after stopping ten years of mass drug administration in rural communities in south India</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Background
While various studies provided insight into the impact of mass drug administration (MDA), information on the dynamics of the post-MDA threshold level lymphatic filariasis (LF) infection facilitates understanding its disappearance pattern and determining the duration of post-MDA monitoring and evaluation.
Methods
The changes in microfilaraemia (Mf) prevalence and vector infection rates were monitored for four (2005-2008) and six years (2005-2010) respectively after stopping ten rounds of annual mass diethylcarbamazine (DEC) administration in a group of five villages located in South India. Four years after stopping MDA, circulating filarial antigenaemia (Ag) status among children and adults was also assessed in two villages.
Results
Overall Mf prevalence (n = 700) and vector infection rates (n=803-3520) showed a declining trend. Two villages maintained zero Mf status in each of the four years, vector infection rate was zero from the third year onwards and Ag prevalence in adults was 0.4% (n = 226). In two other villages despite persistence of Mf and vector infection there was zero vector infectivity rate during the third to sixth year and Ag prevalence among children (n = 50) was nil. In the fifth village Mf prevailed at <1.0% and Ag prevalence among 1-7 year old children was 4.6% (n = 44) and vector infectivity rate during the sixth year was 0.1% (n = 852).
Conclusion
The incidence of sporadic new infections is evident in highly endemic communities such as the fifth village. However, there is uncertainty on the potential of the Ag positive children to reestablish infection. Six years of post-MDA monitoring and evaluation appears to be adequate to discern the status of transmission interruption and appropriate decision making.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases caused by nematodes</subject><subject>Drug Administration Schedule</subject><subject>Drug Monitoring</subject><subject>Elephantiasis, Filarial - epidemiology</subject><subject>Elephantiasis, Filarial - immunology</subject><subject>Elephantiasis, Filarial - transmission</subject><subject>Female</subject><subject>Filariases</subject><subject>General aspects</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Lymphatic filariases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parasitic diseases</subject><subject>Rural Population</subject><subject>Young Adult</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkTtP5DAQgK0T6FjgymuRGySacH7E2CkRggMJiQKoI8exWaM4Dh4baQv--yXaPSipRhp98_oGod-UnFPS8D85QQ7rOWRC6Q-0okqqigvC99CKEC6qhhF-gA4BXglhgormJzpgvK6ZkGyFPh5Lerd-GPRoLI4OD5swrXX2Bjs_6OQ1eMDaZZsw5DhNfnzB2Y54Y3WCpSBoANyn8oJ1H_zoIae5PI7YjziVpAdsYghl9NlbWJIQS17ju7H3-hjtOz2A_bWLR-j55vrp6ra6f_h7d3V5XxkuLnJVi173XadMraRwlgnWMKOZqAkxppeuaTgVxnWMEdF00vZCKuNsV8tOCcsbfoTOtn2nFN-KhdwGD8YuV9tYoKWcScmUqhe02qImRYBkXTslH3TatJS0i_F2a7zdGp_5k13r0gXbf9L_Fc_A6Q7QYPTg0mzawxcnmVR0_tHnjrFM38z8B6fGnN0</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Ramaiah, K.D.</creator><creator>Vanamail, P.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Surveillance of lymphatic filariasis after stopping ten years of mass drug administration in rural communities in south India</title><author>Ramaiah, K.D. ; Vanamail, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-45dadbb8c4875fe25292ca25400ccd7f99315cfb22059b7ed578cfeb47b85e393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases caused by nematodes</topic><topic>Drug Administration Schedule</topic><topic>Drug Monitoring</topic><topic>Elephantiasis, Filarial - epidemiology</topic><topic>Elephantiasis, Filarial - immunology</topic><topic>Elephantiasis, Filarial - transmission</topic><topic>Female</topic><topic>Filariases</topic><topic>General aspects</topic><topic>Helminthic diseases</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Lymphatic filariases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parasitic diseases</topic><topic>Rural Population</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramaiah, K.D.</creatorcontrib><creatorcontrib>Vanamail, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramaiah, K.D.</au><au>Vanamail, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surveillance of lymphatic filariasis after stopping ten years of mass drug administration in rural communities in south India</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>107</volume><issue>5</issue><spage>293</spage><epage>300</epage><pages>293-300</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>Background
While various studies provided insight into the impact of mass drug administration (MDA), information on the dynamics of the post-MDA threshold level lymphatic filariasis (LF) infection facilitates understanding its disappearance pattern and determining the duration of post-MDA monitoring and evaluation.
Methods
The changes in microfilaraemia (Mf) prevalence and vector infection rates were monitored for four (2005-2008) and six years (2005-2010) respectively after stopping ten rounds of annual mass diethylcarbamazine (DEC) administration in a group of five villages located in South India. Four years after stopping MDA, circulating filarial antigenaemia (Ag) status among children and adults was also assessed in two villages.
Results
Overall Mf prevalence (n = 700) and vector infection rates (n=803-3520) showed a declining trend. Two villages maintained zero Mf status in each of the four years, vector infection rate was zero from the third year onwards and Ag prevalence in adults was 0.4% (n = 226). In two other villages despite persistence of Mf and vector infection there was zero vector infectivity rate during the third to sixth year and Ag prevalence among children (n = 50) was nil. In the fifth village Mf prevailed at <1.0% and Ag prevalence among 1-7 year old children was 4.6% (n = 44) and vector infectivity rate during the sixth year was 0.1% (n = 852).
Conclusion
The incidence of sporadic new infections is evident in highly endemic communities such as the fifth village. However, there is uncertainty on the potential of the Ag positive children to reestablish infection. Six years of post-MDA monitoring and evaluation appears to be adequate to discern the status of transmission interruption and appropriate decision making.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>23442572</pmid><doi>10.1093/trstmh/trt011</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0035-9203 |
| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 2013-05, Vol.107 (5), p.293-300 |
| issn | 0035-9203 1878-3503 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1327728849 |
| source | Oxford Journals Online |
| subjects | Adolescent Adult Animals Biological and medical sciences Child Child, Preschool Diseases caused by nematodes Drug Administration Schedule Drug Monitoring Elephantiasis, Filarial - epidemiology Elephantiasis, Filarial - immunology Elephantiasis, Filarial - transmission Female Filariases General aspects Helminthic diseases Humans India - epidemiology Infant Infectious diseases Lymphatic filariases Male Medical sciences Middle Aged Parasitic diseases Rural Population Young Adult |
| title | Surveillance of lymphatic filariasis after stopping ten years of mass drug administration in rural communities in south India |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T14%3A05%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Surveillance%20of%20lymphatic%20filariasis%20after%20stopping%20ten%20years%20of%20mass%20drug%20administration%20in%20rural%20communities%20in%20south%20India&rft.jtitle=Transactions%20of%20the%20Royal%20Society%20of%20Tropical%20Medicine%20and%20Hygiene&rft.au=Ramaiah,%20K.D.&rft.date=2013-05-01&rft.volume=107&rft.issue=5&rft.spage=293&rft.epage=300&rft.pages=293-300&rft.issn=0035-9203&rft.eissn=1878-3503&rft.coden=TRSTAZ&rft_id=info:doi/10.1093/trstmh/trt011&rft_dat=%3Cproquest_cross%3E1327728849%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-45dadbb8c4875fe25292ca25400ccd7f99315cfb22059b7ed578cfeb47b85e393%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1327728849&rft_id=info:pmid/23442572&rft_oup_id=10.1093/trstmh/trt011&rfr_iscdi=true |