Autophagy: Mechanisms, regulation, and its role in tumorigenesis

Autophagy (from Greek “auto” — self, “phagos” — to eat) is the major catabolic process involved in the delivery and lysosomal degradation of long-lived intracellular components: proteins, lipids, nucleic acids, and organelles. Since the discovery of genes involved in regulation of autophagy in the 1...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2013-04, Vol.78 (4), p.355-367
Main Authors: Parkhitko, A. A., Favorova, O. O., Henske, E. P.
Format: Article
Language:English
Subjects:
Animals
Autophagy (Cytology)
Autophagy - physiology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Carcinogenesis
Carcinogenesis - pathology
Cellular biology
Homeostasis
Humans
Life Sciences
Lipids
Microbiology
Nucleic acids
Pathogenesis
Review
Tumors
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Summary:Autophagy (from Greek “auto” — self, “phagos” — to eat) is the major catabolic process involved in the delivery and lysosomal degradation of long-lived intracellular components: proteins, lipids, nucleic acids, and organelles. Since the discovery of genes involved in regulation of autophagy in the 1990s, there has been a significant increase in studies of autophagy as a process involved in maintaining cellular homeostasis, as well as its role in the development of different pathologies. This review focuses on the basics of autophagy and its regulatory mechanisms. The role of autophagy in the maintenance of cellular homeostasis and tumorigenesis is also discussed.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297913040044