Trilevel adaptive servoventilation for the treatment of central and mixed sleep apnea in chronic heart failure patients

• Published in: Sleep medicine 2013-05, Vol.14 (5), p.422-427
• Main Authors: Oldenburg, Olaf, Bitter, Thomas, Wellmann, Birgit, Fischbach, Thomas, Efken, Christina, Schmidt, Anke, Horstkotte, Dieter
• Format: Article
• Language: English
• Subjects: Adaptive servoventilation; Aged; Aged, 80 and over; Cheyne-Stokes respiration; Cheyne-Stokes Respiration - complications; Cheyne-Stokes Respiration - therapy; Chronic Disease; Continuous Positive Airway Pressure - methods; Female; Follow-Up Studies; Heart failure; Heart Failure, Diastolic - complications; Heart Failure, Systolic - complications; Humans; Male; Middle Aged; Mixed sleep apnea; Neurology; Positive airway pressure therapy; Prospective Studies; Sleep Apnea Syndromes - complications; Sleep Apnea Syndromes - therapy; Sleep Medicine; Sleep-disordered breathing; Treatment Outcome
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2012.12.013

Abstract Background Sleep-disordered breathing (SDB) in patients with heart failure (HF) is of major prognostic impact, though treatment of simultaneously occurring central and mixed apnea events is challenging. The objective was to examine long-term effects of a new trilevel adaptive servoventilation (ASV) therapy in patients with systolic or diastolic HF. Methods A total of 45 consecutive patients with a history of HF, elevated N-terminal prohormone of brain natriuretic peptide levels, objective signs of cardiac dysfunction, and moderate to severe SDB (apnea-hypopnea index [AHI] ⩾15/h) with combined central and mixed respiratory events were included in this study and ASV therapy (SOMNO vent CR, Weinmann) was offered. Results In 38 patients (84%), ASV therapy was successfully initiated, with 23 (51%) patients showing appropriate compliance (device use ⩾4 h/night for ⩾5 d/w) after 3.6 ± 1.2 months. In these patients ASV therapy and HF status were re-evaluated. A sustained reduction was achieved in AHI (42.8 ± 17.5/h vs 8.9 ± 5.8/h; p < 0.001) and oxygen saturation. Improvements also were recorded in New York Heart Association (NYHA) functional class (2.4 ± 0.5–1.9 ± 0.4; p < 0.001) and oxygen uptake during cardiopulmonary exercise testing (VO2 peak, 13.64 ± 3.5–15.8 ± 5.8 ml/kg/min; p < 0.002). Conclusion In selected HF patients, trilevel ASV therapy is able to treat SDB with combined central and mixed respiratory events. This treatment is associated with an improvement in HF symptoms and objective cardiopulmonary performance.