Hypoiodite mediated synthesis of isoxazolines from aldoximes and alkenes using catalytic KI and Oxone as the terminal oxidant

Isoxazolines can be efficiently synthesized in good yields via a hypoiodite mediated catalytic oxidative cyclization of aldoximes and alkenes. This reaction involves active iodine species generated in situ from catalytic amounts of KI and Oxone.

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Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (42), p.4800-4802
Main Authors: Yoshimura, Akira, Zhu, Chenjie, Middleton, Kyle R, Todora, Anthony D, Kastern, Brent J, Maskaev, Andrey V, Zhdankin, Viktor V
Format: Article
Language:English
Subjects:
Alkenes - chemistry
Catalysis
Cyclization
Iodine Compounds - chemistry
Isoxazoles - chemistry
Oxidants - chemistry
Oximes - chemistry
Potassium Iodide - chemistry
Sulfuric Acids - chemistry
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cited_by cdi_FETCH-LOGICAL-c353t-b8c1de5160b9eb7a193794a6569f4e02c5879776bc69f393d24da6536c3e3f603
cites cdi_FETCH-LOGICAL-c353t-b8c1de5160b9eb7a193794a6569f4e02c5879776bc69f393d24da6536c3e3f603
container_end_page 4802
container_issue 42
container_start_page 4800
container_title Chemical communications (Cambridge, England)
container_volume 49
creator Yoshimura, Akira
Zhu, Chenjie
Middleton, Kyle R
Todora, Anthony D
Kastern, Brent J
Maskaev, Andrey V
Zhdankin, Viktor V
description Isoxazolines can be efficiently synthesized in good yields via a hypoiodite mediated catalytic oxidative cyclization of aldoximes and alkenes. This reaction involves active iodine species generated in situ from catalytic amounts of KI and Oxone.
doi_str_mv 10.1039/c3cc41164h
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source Royal Society of Chemistry
subjects Alkenes - chemistry
Catalysis
Cyclization
Iodine Compounds - chemistry
Isoxazoles - chemistry
Oxidants - chemistry
Oximes - chemistry
Potassium Iodide - chemistry
Sulfuric Acids - chemistry
title Hypoiodite mediated synthesis of isoxazolines from aldoximes and alkenes using catalytic KI and Oxone as the terminal oxidant
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