Loss of the balance between CD4+ Foxp3+ regulatory T cells and CD4+ IL17A+ Th17 cells in patients with type 1 diabetes

• Published in: Human immunology 2013-06, Vol.74 (6), p.701-707
• Main Authors: Ryba-Stanisławowska, Monika, Skrzypkowska, Maria, Myśliwiec, Małgorzata, Myśliwska, Jolanta
• Format: Article
• Language: English
• Subjects: Adolescent; Allergy and Immunology; Case-Control Studies; Child; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - metabolism; Forkhead Transcription Factors - metabolism; Humans; Interleukin-17 - metabolism; Lymphocyte Count; Neovascularization, Pathologic - immunology; Neovascularization, Pathologic - metabolism; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Th17 Cells - immunology; Th17 Cells - metabolism; Young Adult
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2013.01.024

Abstract The presence of low-grade chronic inflammation is a known feature of long standing diabetes type 1. Recently, two T cell subsets, that may contribute to the disease progression are under investigation. These are Treg cells, which are specialized T cell subset, that controls the activity of autoreactive and inflammatory cells and Th17 cells which are involved in the pathogenesis of inflammatory and autoimmune diseases. The balance between Treg and Th17 controls inflammation and is responsible for the proper function of the immune system. An decrease of Tregs and/or increase of Th17 may induce local inflammation, which in turn may hasten the development of diabetic complications. In the present study, we have demonstrated that the Treg/Th17 balance was broken in patients with diabetes type 1 and might contribute to the progression of microvascular angiopathy.