Postoperative radiotherapy for uterine cervical cancer: impact of lymph node and histological type on survival

• Published in: Anticancer research 2013-05, Vol.33 (5), p.2199-2204
• Main Authors: Kasuya, Goro, Ogawa, Kazuhiko, Iraha, Shiro, Nagai, Yutaka, Hirakawa, Makoto, Toita, Takafumi, Kakinohana, Yasumasa, Kudaka, Wataru, Inamine, Morihiko, Ariga, Takuro, Aoki, Yoichi, Murayama, Sadayuki
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - radiotherapy; Adenocarcinoma - surgery; Adult; Aged; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - surgery; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hysterectomy; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - radiotherapy; Neoplasm Recurrence, Local - surgery; Neoplasm Staging; Pelvic Neoplasms - mortality; Pelvic Neoplasms - radiotherapy; Pelvic Neoplasms - secondary; Pelvic Neoplasms - surgery; Postoperative Period; Prognosis; Retrospective Studies; Survival Rate; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - radiotherapy; Uterine Cervical Neoplasms - surgery; Young Adult
• ISSN: 1791-7530

To retrospectively analyze the treatment results of postoperative radiotherapy (PORT) in patients with early-stage uterine cervical cancer. Records of 141 patients with stage IB-IIB uterine cervical cancer treated with PORT from 1985 to 2004 were retrospectively reviewed. The majority of patients received whole-pelvic radiotherapy with antero-posterior fields, and the total radiation doses ranged from 10.8-60 Gy (median: 50.4 Gy). The median follow-up of all 141 patients was 106 months (range: 0.8-273.7 months). Multivariate analysis revealed that positive lymph node status (p=0.001) and histological type (p=0.015) were independent prognostic factors for overall survival. The group with three or more involved lymph nodes was significantly more likely to have extra-pelvic recurrence when compared with the groups with no (p=0.006) and up to two lymph nodes (p=0.024), respectively. PORT yielded excellent pelvic control rates for early-stage uterine cervical cancer. Lymph node status and histological type were significant prognostic factors for overall survival of patients with these tumors.