Change in Levels of C-Reactive Protein (CRP) and Serum Cortisol in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy

Background C-Reactive protein (CRP) has been associated with the macro- and microvascular effects of hypertension and diabetes mellitus. Referring to serum cortisol, it has been proposed to contribute to the pathogenesis of metabolic syndrome, and it has been demonstrated that weight loss normalizes...

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Bibliographic Details
Published in:Obesity surgery 2013-06, Vol.23 (6), p.764-769
Main Authors: Ruiz-Tovar, Jaime, Oller, Inmaculada, Galindo, Isabel, Llavero, Carolina, Arroyo, Antonio, Calero, Alicia, Diez, María, Zubiaga, Lorea, Calpena, Rafael
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - metabolism
C-Reactive Protein - metabolism
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Cholesterol - metabolism
Clinical Research
Female
Follow-Up Studies
Gastric Bypass - methods
Gastrointestinal surgery
Glycated Hemoglobin A - metabolism
Homeostasis
Hormones
Humans
Hydrocortisone - metabolism
Insulin Resistance
Laparoscopy
Male
Medicine
Medicine & Public Health
Metabolic Syndrome - epidemiology
Metabolic Syndrome - metabolism
Metabolic Syndrome - prevention & control
Middle Aged
Obesity
Obesity, Morbid - epidemiology
Obesity, Morbid - metabolism
Obesity, Morbid - surgery
Postoperative Period
Preoperative Period
Prospective Studies
Proteins
Risk Factors
Spain - epidemiology
Surgery
Treatment Outcome
Triglycerides - metabolism
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Summary:Background C-Reactive protein (CRP) has been associated with the macro- and microvascular effects of hypertension and diabetes mellitus. Referring to serum cortisol, it has been proposed to contribute to the pathogenesis of metabolic syndrome, and it has been demonstrated that weight loss normalizes cortisol levels and improves insulin resistance. The aims of this study were to analyze CRP and cortisol levels pre- and postoperatively in morbidly obese patients undergoing a laparoscopic sleeve gastrectomy and to correlate them with weight loss and parameters associated with cardiovascular risk. Methods A prospective study of all the morbidly obese patients undergoing laparoscopic sleeve gastrectomy as bariatric procedure between October 2007 and May 2011 was performed. Results A total of 40 patients were included in the study. CRP levels decreased significantly 12 months after surgery (median reduction of 8.9 mg/l; p  = 0.001). Serum cortisol levels decreased significantly 6 months after surgery (median reduction of 34.9 μg/dl; p  = 0.001). CRP values reached the normal range (
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-013-0865-7