Alternative Recruitment Strategies Influence Saliva Sample Return Rates in Community‐Based Genetic Association Studies

Summary Collection of saliva for DNA extraction has created new opportunities to recruit participants from the community for genetic association studies. However, sample return rates are variable. No prior study has specifically addressed how study design impacts sample return. Using data from three...

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Bibliographic Details
Published in:Annals of human genetics 2013-05, Vol.77 (3), p.244-250
Main Authors: Bhutta, Mahmood F., Hobson, Lindsey, Lambie, Jane, Scaman, Elizabeth S. H., Burton, Martin J., Giele, Henk, Jamieson, Sarra E., Furniss, Dominic
Format: Article
Language:English
Subjects:
Community‐based studies
Family Characteristics
genetic association
Genetic Association Studies
Genetics
Genetics, Population - methods
Hotlines - statistics & numerical data
Humans
Oragene
Patient Participation - statistics & numerical data
Patient Selection
Prospective Studies
Retrospective Studies
return rates
Saliva - cytology
saliva sample
Specimen Handling - methods
Specimen Handling - statistics & numerical data
Studies
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Summary:Summary Collection of saliva for DNA extraction has created new opportunities to recruit participants from the community for genetic association studies. However, sample return rates are variable. No prior study has specifically addressed how study design impacts sample return. Using data from three large‐scale genetic association studies we compared recruitment strategy and sample return rates. We found highly significant differences in sample return rates between the studies. In studies that recruited retrospectively, overall returns were much lower from families with a self‐limiting condition who provided samples at a research centre or home visit, than adult elderly individuals with a chronic disease who provided samples by post (59% vs. 84%). Prospective recruitment was associated with high agreement to participate (72%), but subsequent low return of actual saliva samples (42%). A telephone call had marginal effect on recruitment in a retrospective family study, but significantly improved returns in a prospective family study. We found no effect upon DNA yield comparing observed versus unobserved sample collection, or between male and female adult participants. Overall, study design significantly impacts upon response rates for genetic association studies recruiting from the community. Our findings will help researchers in constructing and costing a recruitment protocol.
ISSN:0003-4800
1469-1809
DOI:10.1111/ahg.12009