Cancer Incidence Following Treatment of Hyperthyroidism

Hoffman D A (Environmental Epidemiology Branch, National Cancer Institute, Room 3c–07, London Bldg., Bethesda MD 20205, USA), McConahey W M, Fraumeni, J F and Kurland L T. Cancer incidence following treatment of hyperthyroidism. International Journal of Epidemiology, 1982, 11: 218–224 A retrospectiv...

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Bibliographic Details
Published in:International journal of epidemiology 1982-09, Vol.11 (3), p.218-224
Main Authors: HOFFMAN, DANIEL A., McCONAHEY, WILLIAM M., FRAUMENI, JOSEPH F., KURLAND, LEONARD T.
Format: Article
Language:English
Subjects:
Age Factors
Female
Follow-Up Studies
Humans
Hyperthyroidism - radiotherapy
Hyperthyroidism - surgery
Iodine Radioisotopes - adverse effects
Iodine Radioisotopes - therapeutic use
Neoplasms, Radiation-Induced - etiology
Radiotherapy Dosage
Retrospective Studies
Risk
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Summary:Hoffman D A (Environmental Epidemiology Branch, National Cancer Institute, Room 3c–07, London Bldg., Bethesda MD 20205, USA), McConahey W M, Fraumeni, J F and Kurland L T. Cancer incidence following treatment of hyperthyroidism. International Journal of Epidemiology, 1982, 11: 218–224 A retrospective cohort study of women treated for hyperthyroidism at the Mayo Clinic was conducted to evaluate the risk of cancer according to type of therapy. One or more years after the start of treatment, there were 105 cases of cancer observed among 1005 women treated with radioiodine (131I) and 247 cases among 2141 women treated with surgery. No difference was observed between the two study groups for total cancer incidence (RR = 1.0), breast cancer (RR = 0.8), or leukaemia (RR = 0.6). Although based on small numbers of cases, an elevated risk of cancer was observed in organs that concentrate 131I (salivary glands, digestive tract, kidney and bladder) (RR = 1.8). While the findings are suggestive, they indicate the need for larger surveys to evaluate the carcinogenic potential of 131I.
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/11.3.218