Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents

• Published in: The American journal of clinical nutrition 2013-06, Vol.97 (6), p.1228-1234
• Main Authors: Gergen, Peter J, Teach, Stephen J, Mitchell, Herman E, Freishtat, Robert F, Calatroni, Agustin, Matsui, Elizabeth, Kattan, Meyer, Bloomberg, Gordon R, Liu, Andrew H, Kercsmar, Carolyn, O'Connor, George, Pongracic, Jacqueline, Rivera-Sanchez, Yadira, Morgan, Wayne J, Sorkness, Christine A, Binkley, Neil, Busse, William
• Format: Article
• Language: English
• Subjects: Adolescent; adolescents; African Americans; Asthma; Asthma - blood; Asthma - complications; Asthma - epidemiology; Biological and medical sciences; Black or African American; blood serum; Child; Chronic obstructive pulmonary disease, asthma; clinical nutrition; Correlation analysis; Cross-Sectional Studies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; Linear Models; Male; Medical sciences; Medical treatment; Mexican Americans; Morbidity; Multivariate Analysis; National Health and Nutrition Examination Survey; Nutrition Surveys; Pneumology; Prevalence; Randomized Controlled Trials as Topic; Teenagers; therapeutics; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; White People; Young Adult
• ISSN: 0002-9165; 1938-3207
• DOI: 10.3945/ajcn.112.046961

Background: Decreased 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with an increased prevalence and severity of asthma and a lower response to inhaled corticosteroids.Objective: The objective was to determine the association between serum 25(OH)D concentrations and asthma prevalence, severity, and response to asthma treatment.Design: Secondary analyses were conducted in 2 samples of adolescents 12–20 y of age: 1) NHANES 2001–2006 (n = 6487), a cross-sectional nationally representative sample of the US population, and 2) a cohort of inner-city adolescents with asthma managed prospectively for 46 wk with guidelines-based therapy in the Asthma Control Evaluation (ACE; n = 226) trial.Results: Mean (±SD) serum 25(OH)D concentrations in the NHANES and ACE samples were lower in African Americans than in non–African Americans (NHANES: 14.9 ± 6.5 compared with 23.0 ± 8.4 ng/mL, P < 0.0001; ACE: 11.2 ± 6.9 compared with 15.8 ± 7.1 ng/mL, P < 0.0001). In the NHANES sample, mean concentrations did not differ between participants without and with asthma (African Americans: 14.9 ± 6.4 compared with 15.0 ± 6.6 ng/mL, respectively, P = 0.87; non–African Americans: 23.0 ± 8.5 compared with 23.6 ± 8.2 ng/mL, respectively, P = 0.16). In the ACE models that used either a predefined cutoff (