Correlation between salivary interleukin-6 levels and early locoregional recurrence in patients with oral squamous cell carcinoma: Preliminary study

Background We have demonstrated that salivary interleukin‐6 (IL‐6) concentrations change during the treatment in patients with oral squamous cell carcinoma (OSCC). We sought to elucidate the correlations between salivary IL‐6 concentration and early locoregional recurrence in OSCC. Methods Stimulate...

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Bibliographic Details
Published in:Head & neck 2013-06, Vol.35 (6), p.889-894
Main Authors: Sato, Jun, Ohuchi, Manabu, Abe, Keigo, Satoh, Takehiko, Abe, Takahiro, Yamazaki, Yutaka, Satoh, Akira, Notani, Ken-ichi, Kitagawa, Yoshimasa
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - therapy
Case-Control Studies
Chemotherapy, Adjuvant
Female
Humans
interleukin-6
Interleukin-6 - metabolism
locoregional recurrence
Male
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - therapy
Multivariate Analysis
Neck Dissection
Neoplasm Recurrence, Local - metabolism
oral squamous cell carcinoma
Postoperative Period
Preoperative Period
prognosis
Prospective Studies
Radiotherapy, Adjuvant
Risk Factors
saliva
Saliva - metabolism
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Summary:Background We have demonstrated that salivary interleukin‐6 (IL‐6) concentrations change during the treatment in patients with oral squamous cell carcinoma (OSCC). We sought to elucidate the correlations between salivary IL‐6 concentration and early locoregional recurrence in OSCC. Methods Stimulated saliva was collected before and after surgery from 27 consecutive patients with OSCC. Recurrence‐free survival (RFS) curves were plotted using the Kaplan–Meier method. Results Of the 27 patients, 11 (41%) were diagnosed with locoregional recurrence within 24 months postsurgery. The median concentrations of IL‐6 presurgery and postsurgery were 2.8 pg/mL and 2.1 pg/mL, respectively. The median postsurgery concentration of IL‐6 was significantly higher in patients with than without locoregional recurrence (p = .02). Multivariate analysis revealed that postsurgery salivary IL‐6 concentration was an independent risk factor for locoregional recurrence (p = .03; risk ratio, 0.14). Conclusions Posttreatment concentration of salivary IL‐6 may predict early locoregional recurrence in OSCC. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.23056