Retinal white blood cell flux and systemic blood pressure in patients with type 1 diabetes

Aims There is evidence that altered retinal blood flow and altered retinal blood flow regulation play a role in the development and progression of diabetic retinopathy. We compared the association between systemic blood pressure and retinal white blood cell flux in patients with type 1 diabetes and...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2013-06, Vol.251 (6), p.1475-1481
Main Authors: Palkovits, Stefan, Fuchsjäger-Mayrl, Gabriele, Kautzky-Willer, Alexandra, Richter-Müksch, Sibylla, Prinz, Ana, Vécsei-Marlovits, Veronika, Garhöfer, Gerhard, Schmetterer, Leopold
Format: Article
Language:English
Subjects:
Adult
Blood Flow Velocity - physiology
Blood Glucose - metabolism
Blood Pressure - physiology
Diabetes Mellitus, Type 1 - physiopathology
Diabetic Retinopathy - physiopathology
Female
Glycated Hemoglobin A - metabolism
Homeostasis
Humans
Intraocular Pressure - physiology
Laser-Doppler Flowmetry
Leukocytes - physiology
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Retinal Disorders
Retinal Vessels - physiopathology
Tonometry, Ocular
Young Adult
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Summary:Aims There is evidence that altered retinal blood flow and altered retinal blood flow regulation play a role in the development and progression of diabetic retinopathy. We compared the association between systemic blood pressure and retinal white blood cell flux in patients with type 1 diabetes and healthy control subjects. Methods The study was performed in 100 patients with type 1 diabetes with no or minimal diabetic retinopathy and a group of 313 age-matched healthy controls. Inclusion criteria were systolic blood pressure ≤160 mmHg and diastolic blood pressure ≤95 mmHg. None of the subjects took vasoactive medication except insulin. The blue field entoptic technique was used to assess retinal white blood cell flux, velocity and density in the perimacular region. Pressure–flow relationships were calculated for both groups to assess differences in blood flow regulation. Results Retinal white blood cell flux was comparable between the two study groups. Both type 1 diabetic patients and healthy subjects showed a significant positive correlation between retinal white blood cell flux and mean arterial pressure (diabetic patients: r  = 0.48; p  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-012-2193-3