Association Between SLC1A1 Gene and Early-Onset OCD in the Han Chinese Population: A Case–Control Study

Obsessive–compulsive disorder (OCD) is a common and severe mental illness, and its etiology still remains unknown. The glutamate transporter gene solute carrier family 1, member 1 was previously tested as a promising candidate for OCD by several research groups. However, subsequent studies were not...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2013-06, Vol.50 (2), p.353-359
Main Authors: Wu, Haisu, Wang, Xuemei, Xiao, Zeping, Yu, Shunying, Zhu, Liping, Wang, Dongxiang, Jiang, Kaida, Wang, Zhen, Zhang, Tianhong, Fralick, Drew
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age of Onset
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cell Biology
Child, Preschool
China
Etiology
Excitatory Amino Acid Transporter 3 - genetics
Female
Gender
Gene Frequency
Genetic Association Studies
Haplotypes
Humans
Male
Mental disorders
Mental health
Neurochemistry
Neurology
Neurosciences
Obsessive-Compulsive Disorder - epidemiology
Obsessive-Compulsive Disorder - genetics
Polymorphism, Single Nucleotide
Proteomics
Twin studies
Twins
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Summary:Obsessive–compulsive disorder (OCD) is a common and severe mental illness, and its etiology still remains unknown. The glutamate transporter gene solute carrier family 1, member 1 was previously tested as a promising candidate for OCD by several research groups. However, subsequent studies were not consistent. OCD is a heterogeneous disease. Early-onset OCD is a demographically and clinically distinct subtype of OCD and may be a more homogeneous subtype. Gender-matched 244 early-onset OCD patients, 244 late-onset OCD patients, and 244 healthy controls were genotyped with four SNPs (rs10491734, rs2228622, rs301430, and rs301443) through TaqMan SNP genotyping assays. There were statistical differences in allele and genotype frequencies of rs10491734 in early-onset OCD patients compared to late-onset OCD or control subjects. The haplotype analysis showed that the four-locus haplotype (A-A-C-C and A-G-C-C) were associated with early onset obsessive–compulsive disorder after Bonferroni correction. The present study provided suggestive evidence that the rs10491734 was significantly associated with early-onset OCD in the Han Chinese population. However, these findings need further replication.
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-013-9995-6