Nutrient-Deprivation Autophagy Factor-1 (NAF-1): Biochemical Properties of a Novel Cellular Target for Anti-Diabetic Drugs

Nutrient-deprivation autophagy factor-1 (NAF-1) (synonyms: Cisd2, Eris, Miner1, and Noxp70) is a [2Fe-2S] cluster protein immune-detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane. It was implicated in human pathology (Wolfram Syndrome 2) and in BCL-2 mediated antagonizatio...

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Published in:	PloS one 2013-05, Vol.8 (5), p.e61202
Main Authors:	Tamir, Sagi, Zuris, John A., Agranat, Lily, Lipper, Colin H., Conlan, Andrea R., Michaeli, Dorit, Harir, Yael, Paddock, Mark L., Mittler, Ron, Cabantchik, Zvi Ioav, Jennings, Patricia A., Nechushtai, Rachel
Format:	Article
Language:	English
Subjects:	Antidiabetics Antioxidants Autophagy Bcl-2 protein Biochemistry Biology Calcium Cell culture Cell death Cells, Cultured Chemistry Clusters Deprivation Diabetes Diabetes mellitus Drug Delivery Systems - methods Drugs Electrophoresis Endoplasmic reticulum Eris (dwarf planet) Fluorescence Fluorides Human pathology Humans Hypoglycemic agents Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Immunosuppressive agents Iron Iron - metabolism Kinases Life sciences Ligands Mental depression Mitochondria Mitochondria - drug effects Mitochondria - metabolism Molecular structure Natural products Nutrients Oxidation-Reduction - drug effects Oxidative stress Phagocytosis Physics Pioglitazone Properties (attributes) Protein Subunits - metabolism Proteins Resveratrol Ribonucleoproteins - metabolism Small Molecule Libraries - metabolism Small Molecule Libraries - therapeutic use Spectrophotometry Sulfur Thiazolidinediones - metabolism Thiazolidinediones - pharmacology
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