Racial disparity in colorectal cancer: the role of ABO blood group

Abstract Background We tested the hypothesis that racial differences that exist in the distribution of ABO blood type would partially explain the racial disparity in overall survival seen in colorectal cancer. Methods retrospective analysis of the cancer registry of a university hospital for patient...

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Bibliographic Details
Published in:The Journal of surgical research 2013-07, Vol.183 (1), p.230-237
Main Authors: Laryea, Jonathan A., MD, FACS, FASCRS, Siegel, Eric, MS, Burford, Jeffrey M., MD, Klimberg, Suzanne V., MD, FACS
Format: Article
Language:English
Subjects:
ABO blood type
ABO Blood-Group System
Academic Medical Centers - statistics & numerical data
Aged
Arkansas - epidemiology
Colorectal cancer
Colorectal Neoplasms - ethnology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - therapy
Disparity
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Race
Registries
Retrospective Studies
Surgery
Survival
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Summary:Abstract Background We tested the hypothesis that racial differences that exist in the distribution of ABO blood type would partially explain the racial disparity in overall survival seen in colorectal cancer. Methods retrospective analysis of the cancer registry of a university hospital for patients treated for colorectal cancer between 1996 and 2008. Demographic, tumor-specific, and treatment-specific variables were abstracted. We also obtained ABO blood group data. The primary end point was overall survival. We divided patients into two groups based on where they underwent surgery: the University of Arkansas for Medical Sciences (UAMS) or outside facilities. Results Of 833 patients, 182 (21.8%) were black. There was no difference in overall survival between blacks and whites for the entire group ( P = 0.61). There was a statistically significant difference in overall survival between patients at the UAMS and outside facilities ( P < 0.0001). For the outside facilities group, there was a statistically significant difference in overall survival between blacks and whites (hazard ratio, CI: 1.48 [1.06–2.00]; P  = 0.012); no race difference existed for the UAMS group. The ABO blood group had no effect on overall survival. On stage-stratified univariate and multivariate analyses, chemotherapy and surgery were the only statistically significant determinants of survival. Conclusions In this study, racial differences in ABO blood group distribution had no effect on overall survival.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2012.11.039