Low calcium intake and inadequate vitamin D status in postmenopausal osteoporotic women

• Published in: The Journal of steroid biochemistry and molecular biology 2013-07, Vol.136, p.175-177
• Main Authors: Quesada-Gómez, José Manuel, Diaz-Curiel, Manuel, Sosa-Henriquez, Manuel, Malouf-Sierra, Jorge, Nogues-Solan, Xavier, Gomez-Alonso, Carlos, Rodriguez-Mañas, Leocadio, Neyro-Bilbao, Jose Luis, Cortes, Xavier, Delgadillo, Joaquín
• Format: Article
• Language: English
• Subjects: Aged; Bone Density Conservation Agents - therapeutic use; Calcium intake; Calcium, Dietary - administration & dosage; Calcium, Dietary - metabolism; Cross-Sectional Studies; Female; Humans; Inadequate response; Nutritional Status; Osteoporosis treatment; Osteoporosis, Postmenopausal - blood; Osteoporosis, Postmenopausal - complications; Osteoporosis, Postmenopausal - therapy; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D deficiency; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D insufficiency
• ISSN: 0960-0760; 1879-1220
• DOI: 10.1016/j.jsbmb.2012.10.013

▸ Prevalence of vitamin D deficiency is high in osteoporotic postmenopausal women. ▸ Vitamin D deficiency persists amongst osteoporotic women under treatment. ▸ Dietary calcium intake is well below the commonly established recommendations. ▸ This can be related to low therapeutic adherence and/or insufficient prescription. An observational cross-sectional study was conducted to assess calcium intake and vitamin D status by measurement of 25-hydroxyvitamin D (25(OH)D), in postmenopausal osteoporotic women (PMOW) treated and untreated for osteoporosis. To assess the influence of sunlight exposure on vitamin D status, the study group was categorized on the basis of sunlight exposure (above or below 2500 sunlight h/year). A group of 336 PMOW older than 65 years was identified (190 [56.5%] treated and 146 [43.5%] untreated for osteoporosis). The demographic and clinical data of the PMO women included history of prior fractures, pharmacological treatments and dietary calcium intake. BMD was measured by DEXA and 25(OH)D was determined by an HPLC method. Results: vitamin D serum levels were lower in the untreated group as compared with the treated group (58±27 vs. 67±27nmol/l; p=0.006). Prevalence of vitamin D deficiency (cut-off point set at