Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis

Summary Background Although incrimination of the intestinal microbiota in the pathogenesis of IBD is widely accepted, few data are available about the role of specific bacteria. Potentially, Faecalibacterium prausnitzii, bacteria with anti‐inflammatory properties, might be deficient in ulcerative co...

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Published in:Alimentary pharmacology & therapeutics 2013-07, Vol.38 (2), p.151-161
Main Authors: Varela, E., Manichanh, C., Gallart, M., Torrejón, A., Borruel, N., Casellas, F., Guarner, F., Antolin, M.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Colitis, Ulcerative - microbiology
Cross-Sectional Studies
Digestive system
Feces - microbiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gram-Positive Bacteria - isolation & purification
Gram-Positive Bacterial Infections - microbiology
Humans
Leukocyte L1 Antigen Complex - metabolism
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Pedigree
Pharmacology. Drug treatments
Real-Time Polymerase Chain Reaction
Recurrence
Ruminococcus - isolation & purification
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Young Adult
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Summary:Summary Background Although incrimination of the intestinal microbiota in the pathogenesis of IBD is widely accepted, few data are available about the role of specific bacteria. Potentially, Faecalibacterium prausnitzii, bacteria with anti‐inflammatory properties, might be deficient in ulcerative colitis (UC). Aim To quantify F. prausnitzii in the faecal microbiota of UC patients in remission and determine its relationship with relapse. Methods A cross‐sectional study included 116 UC patients in remission, 29 first‐degree relatives and 31 healthy controls. A subset of eighteen patients, recruited during the first month of remission, underwent a 1‐year follow‐up. Total bacteria and F. prausnitzii were measured by quantitative Real Time PCR (qPCR, copies/g). Calprotectin was determined as inflammatory index (μg/g). Results We found that F. prausnitzii was reduced in patients (median, IQR: 1.4 × 108, 5.1 × 107–4.5 × 108) and relatives (1.7 × 108, 9.3 × 107–5.1 × 108) vs. controls (6.5 × 108, 3.7 × 108–1.6 × 109, P 
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.12365