CD19 expression in acute leukemia is not restricted to the cytogenetically aberrant populations

Abstract Aberrant expression of the B lymphoid marker, CD19, in acute myeloid leukemia (AML) has frequently been associated with t(8;21)(q22;q22). However, AML cases lacking t(8;21) may occasionally express CD19. We asked whether CD19 expression is restricted to the karyotypically abnormal leukemic...

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Bibliographic Details
Published in:Leukemia & lymphoma 2013-07, Vol.54 (7), p.1517-1520
Main Authors: Francis, Jawad, Dharmadhikari, Avinash V., Sait, Sheila N. J., Deeb, George, Wallace, Paul K., Thompson, James E., Wang, Eunice S., Wetzler, Meir
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Antigens, CD19 - genetics
Antigens, CD19 - metabolism
CD19
Chromosome Aberrations
flow cytometry
fluorescence in situ hybridization
Gene Expression
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - metabolism
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Summary:Abstract Aberrant expression of the B lymphoid marker, CD19, in acute myeloid leukemia (AML) has frequently been associated with t(8;21)(q22;q22). However, AML cases lacking t(8;21) may occasionally express CD19. We asked whether CD19 expression is restricted to the karyotypically abnormal leukemic cells in primary leukemia samples. We compared, by fluorescence in situ hybridization, CD19-positive and CD19-negative cells from nine patients with acute leukemia: three non-t(8;21) AML, three t(8;21) AML and three cases of acute lymphoblastic leukemia. There were no significant differences in karyotypic pattern between the CD19-positive and CD19-negative leukemic cells, raising the concern that therapeutically targeting CD19 for acute leukemia may not eradicate all malignant clones.
ISSN:1042-8194
1029-2403
1029-2403
DOI:10.3109/10428194.2012.754096