Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study

• Published in: Lancet neurology 2013-05, Vol.12 (5), p.454-461
• Main Authors: Amin, Faisal Mohammad, MD, Asghar, Mohammad Sohail, MD, Hougaard, Anders, MD, Hansen, Adam Espe, PhD, Larsen, Vibeke Andrée, MD, de Koning, Patrick JH, MSc, Larsson, Henrik BW, Prof, Olesen, Jes, Prof, Ashina, Messoud, Dr
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Blood Flow Velocity - physiology; Brain - blood supply; Carbon dioxide; Carotid Arteries - diagnostic imaging; Cerebral Arteries - diagnostic imaging; Cerebrovascular Circulation - physiology; Cross-Sectional Studies; Female; Headaches; Hospitals; Humans; Hypotheses; Magnetic Resonance Angiography; Male; Medical imaging; Meningeal Arteries - diagnostic imaging; Middle Aged; Migraine; Migraine without Aura - diagnostic imaging; Migraine without Aura - physiopathology; Neurology; Pain; Radiography; Veins & arteries
• ISSN: 1474-4422; 1474-4465
• DOI: 10.1016/S1474-4422(13)70067-X

Summary Background Extracranial arterial dilatation has been hypothesised to be the cause of pain in patients who have migraine without aura. To test that hypothesis, we aimed to measure extracranial and intracranial arteries during attacks of migraine without aura. Methods In this cross-sectional study, we recruited patients aged 18–60 years from the Danish Headache Centre and via announcements on a Danish website. We did magnetic resonance angiography during spontaneous unilateral migraine attacks. Primary endpoints were difference in circumference of extracranial and intracranial arterial segments comparing attack and attack-free days and the pain and the non-pain side. The extracranial arterial segments measured were the external carotid (ECA), the superficial temporal (STA), the middle meningeal (MMA), and the cervical part of the internal carotid (ICAcervical ) arteries. The intracranial arterial segments were the cavernous (ICAcavernous ) and cerebral (ICAcerebral ) parts of the internal carotid, the middle cerebral (MCA), and the basilar (BA) arteries. This study is registered at Clinicaltrials.gov , number NCT01471314. Findings Between Oct 12, 2010, and Feb 8, 2012, we recruited 78 patients, of whom 19 women had a scan during migraine and were included in the final analysis. On migraine compared with non-migraine days, we detected no statistically significant dilatation of the extracranial arteries on the pain side (ECA, mean difference 1·2% [95% CI −5·7 to 8·2] p=0·985, STA 3·6% [–3·7 to 11·0] p=0·532, MMA 1·7% [–1·7 to 5·2] p=0·341, and ICAcervical 2·3% [–0·3 to 4·9] p=0·093); the intracranial arteries were more dilated during attacks (MCA, 13·0% [6·4 to 19·6] p=0·001, ICAcerebral 11·5% [5·6 to 17·3] p=0·0004, and ICAcavernous 11·4% [5·3 to 17·5] p=0·001), except for the BA (1·6% [–2·7 to 5·9] p=0·621). Compared with the non-pain side, during attacks we detected dilatation on the pain side of the intracranial arteries (MCA, mean difference 10·5% [0·7–20·3] p=0·044, ICAcerebral (14·4% [4·6–24·1] p=0·013), and ICAcavernous (9·1% [3·9–14·4] p=0·003) but not of the extracranial arteries (ECA, 2·1% [–3·8 to 9·2] p=0·238, STA, 3·6% [–3·7 to 10·8] p=0·525, MMA, 2·7% [–1·3 to 5·6] p=0·531, and ICAcervical , 5·0% [–0·5 to 10·4] p=0·119). Interpretation Migraine pain was not accompanied by extracranial arterial dilatation, and by only slight intracranial dilatation. Future migraine research should focus on the peripheral and central pain pathways rather t