Measuring Adherence to Antiretroviral Treatment: The Role of Pharmacy Records of Drug Withdrawals

This study aimed to evaluate adherence to antiretroviral treatment (ART) among HIV + adults, assess its association with HIV viral load (VL) and identify factors associated to adherence. A survey involving a random sample of adults followed at a HIV/AIDS reference center in São Paulo city, Brazil, f...

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Bibliographic Details
Published in:AIDS and behavior 2012-08, Vol.16 (6), p.1482-1490
Main Authors: Gutierrez, Eliana Battaggia, Sartori, Ana Marli Christovam, Schmidt, Ana Lucia, Piloto, Bruna Mamprim, França, Bruna Biagi, de Oliveira, Adriana Santos, Pouza, Adriana Rodrigues, Moreno, Roberta Vilela, de Melo Picone, Camila, de Almeida Ribeiro, Manoel Carlos Sampaio
Format: Article
Language:English
Subjects:
Acquired Immune Deficiency Syndrome
Adult
Aged
Ambulatory Care Facilities
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Brazil
Compliance
Cross-Sectional Studies
Drug Prescriptions - statistics & numerical data
Female
Health Psychology
HIV
HIV Infections - drug therapy
HIV Infections - virology
Human immunodeficiency virus
Humans
Infectious Diseases
Logistic Models
Male
Males
Medical records
Medical Records Systems, Computerized
Medication Adherence
Medications
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Original Paper
Pharmacy
Pharmacy Service, Hospital
Public Health
Records as Topic
Sao Paulo, Brazil
Self Report
Socioeconomic Factors
Surveys and Questionnaires
Symptoms
Treatment
Viral Load
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Description
Summary:This study aimed to evaluate adherence to antiretroviral treatment (ART) among HIV + adults, assess its association with HIV viral load (VL) and identify factors associated to adherence. A survey involving a random sample of adults followed at a HIV/AIDS reference center in São Paulo city, Brazil, from 2007 to 2009 was done. A questionnaire was applied and data were retrieved from the pharmacy and medical records. The study involved 292 subjects: 70.2% men; median age: 43 years; median duration of ART: 8 years. 89.3% self-reported taken all prescribed pills in the last 3 days but only 39.3% picked up ≥95% of the prescribed ART from the pharmacy in the last 12 months. At the multivariate analysis having symptoms prior to ART, taking fewer ART pills, and not missing medical appointments were independently associated to higher adherence. Adherence was strongly associated with undetectable HIV VL. Rates of undetectable HIV VL did not differ from 80 to ≥95% of adherence.
ISSN:1090-7165
1573-3254
DOI:10.1007/s10461-012-0168-3