Storage of Hydrogen Spin Polarization in Long-Lived 13C2 Singlet Order and Implications for Hyperpolarized Magnetic Resonance Imaging

Hyperpolarized magnetic resonance imaging (MRI) is a powerful technique enabling real-time monitoring of metabolites at concentration levels not accessible by standard MRI techniques. A considerable challenge this technique faces is the T 1 decay of the hyperpolarization upon injection into the syst...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2013-07, Vol.135 (26), p.9632-9635
Main Authors: Feng, Yesu, Theis, Thomas, Liang, Xiaofei, Wang, Qiu, Zhou, Pei, Warren, Warren S
Format: Article
Language:English
Subjects:
Acetylene - analogs & derivatives
Acetylene - chemistry
Carbon Isotopes
Hydrogen - chemistry
Magnetic Resonance Imaging
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Summary:Hyperpolarized magnetic resonance imaging (MRI) is a powerful technique enabling real-time monitoring of metabolites at concentration levels not accessible by standard MRI techniques. A considerable challenge this technique faces is the T 1 decay of the hyperpolarization upon injection into the system under study. Here we show that A n A′ n XX′ spin systems such as 13C2-1,2-diphenylacetylene (13C2-DPA) sustain long-lived polarization for both 13C and 1H spins with decay constants of almost 4.5 min at high magnetic fields of up to 16.44 T without spin-locking; the T 1 of proton polarization is only 3.8 s. Therefore, storage of the proton polarization in a 13C2-singlet state causes a 69-fold extension of the spin lifetime. Notably, this extension is demonstrated with proton-only pulse sequences, which can be readily implemented on standard clinical scanners.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja404936p