Clearance of osteocalcin by continuous ambulatory peritoneal dialysis in renal failure

Osteocalcin is a calcium-binding protein of about 6000 mw which can be detected in human serum by RIA. Derived from bone and cleared by the kidney, circulating osteocalcin is markedly elevated by renal failure. The authors observed that hemodialysis (HD) patients have somewhat higher serum osteocalc...

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Bibliographic Details
Published in:Calcified tissue international 1983-01, Vol.35 (4-5)
Main Authors: Cole, DEC, Gundberg, C M, Hanning, R M, Zlotkin, SH, Balfe, J W, Gallop, P M
Format: Article
Language:English
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Summary:Osteocalcin is a calcium-binding protein of about 6000 mw which can be detected in human serum by RIA. Derived from bone and cleared by the kidney, circulating osteocalcin is markedly elevated by renal failure. The authors observed that hemodialysis (HD) patients have somewhat higher serum osteocalcins than those on continuous ambulatory peritoneal dialysis (CAPD). Furthermore, random samples of peritoneal dialysate contain significant amounts of osteocalcin, whereas hemodialysate contains no osteocalcin. It was conclude that CAPD, unlike HD, removes a significant portion of circulating osteocalcin but does not restore values to normal. The authors speculate that the different spectrum of bone disorders seen in CAPD, as opposed to HD patients, may be in part related to differences in clearance of this abundant bone-specific protein.
ISSN:0171-967X