Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters

Cecal ligation and puncture (CLP) is the sepsis model that more closely resembles the human pathology, but it is likely to cause suffering to experimental animals. However, it is not clear whether the use of analgesia may affect some parameters evaluated in experimental sepsis research. Therefore, w...

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Bibliographic Details
Published in:Fundamental & clinical pharmacology 2013-08, Vol.27 (4), p.347-353
Main Authors: Nardi, Geisson Marcos, Bet, Angela Cristina, Sordi, Regina, Fernandes, Daniel, Assreuy, Jamil
Format: Article
Language:English
Subjects:
analgesia
Analgesics, Opioid - pharmacology
Animals
Biochemical Phenomena - drug effects
Biological and medical sciences
Body Temperature - drug effects
Body Weight - drug effects
Cardiovascular System - drug effects
Cardiovascular System - metabolism
Cardiovascular System - physiopathology
cecal ligation and puncture
Disease Models, Animal
Eating - drug effects
Eating - physiology
Female
fentanyl
Fentanyl - pharmacology
Hemodynamics - drug effects
Hemodynamics - physiology
Medical sciences
pain
Pharmacology. Drug treatments
Rats
sepsis
Sepsis - drug therapy
Sepsis - mortality
Sepsis - physiopathology
tramadol
Tramadol - pharmacology
Water - metabolism
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Summary:Cecal ligation and puncture (CLP) is the sepsis model that more closely resembles the human pathology, but it is likely to cause suffering to experimental animals. However, it is not clear whether the use of analgesia may affect some parameters evaluated in experimental sepsis research. Therefore, we investigated the effects of fentanyl and tramadol in experimental sepsis in the rat. The following parameters were evaluated: body temperature, body weight, water and food ingestion, mortality, analgesia, blood leukocytes, mean arterial blood pressure, vascular reactivity to phenylephrine, lung myeloperoxidase activity, and plasma levels of IL1‐β, glutamic‐oxaloacetic, glutamic‐pyruvic, lactate, creatinine and urea. While producing significant analgesia, the opioids modify minimally the parameters, with the exception of sepsis‐induced hypotension and mortality. Although fentanyl and tramadol can minimize pain and the general suffering of animals submitted to CLP surgery, their effects on cardiovascular parameters as well as in the mortality indicate that their use in experimental sepsis must be done with caution and with all the proper control groups.
ISSN:0767-3981
1472-8206
DOI:10.1111/j.1472-8206.2012.01041.x