Continuous increase of the antimicrobial resistance among gram-negative pathogens causing bacteremia: a nationwide surveillance study by the Korean Network for Study on Infectious Diseases (KONSID)

Abstract Antimicrobial susceptibility data for all microorganisms isolated from blood culture were collected from 13 institutions in Korea from June to September 2011. Data were compared with our previous studies performed during 2006–2007 and 2008. The prevalence of MRSA in 2011 has rebounded to 63...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2013-08, Vol.76 (4), p.477-482
Main Authors: Huh, Kyungmin, Kim, Jungok, Cho, Sun Young, Ha, Young Eun, Joo, Eun-Jeong, Kang, Cheol-In, Chung, Doo Ryeon, Lee, Nam Yong, Song, Jae-Hoon, Peck, Kyong Ran
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Bacteremia
Bacteremia - drug therapy
Bacteremia - epidemiology
Bacteremia - microbiology
beta-Lactamases - genetics
beta-Lactamases - metabolism
Drug resistance
Drug Resistance, Multiple, Bacterial
Epidemiological Monitoring
Epidemiology
Gene Expression
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - physiology
Gram-Negative Bacterial Infections - drug therapy
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - microbiology
Humans
Infectious Disease
Internal Medicine
Prevalence
Republic of Korea - epidemiology
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Summary:Abstract Antimicrobial susceptibility data for all microorganisms isolated from blood culture were collected from 13 institutions in Korea from June to September 2011. Data were compared with our previous studies performed during 2006–2007 and 2008. The prevalence of MRSA in 2011 has rebounded to 63.7% after a slight decrease in 2008. Vancomycin-resistant Enterococcus faecium declined to 24.1%. The resistance rates of Acinetobacter baumannii to imipenem and meropenem increased from 25.4% and 28.8% to 55.4% and 37.5%, respectively. Ciprofloxacin resistance of Escherichia coli has increased from 23.9% to 30.8%. The resistance rate of Klebsiella pneumoniae to ciprofloxacin has increased from 17.7% to 26.5%. Extended spectrum beta-lactamase–producing E. coli and K. pneumoniae have also seen increased levels of resistance, from 8.6% to 18.4% and 13.6% to 28.5%, respectively. An overall increase in antimicrobial resistance among gram-negative pathogens has been observed. Continued surveillance and intervention to slow the propagation of resistance are necessary.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2013.04.014