Structural identification of the purine ring-opened form of N-(deoxyguanosin-8-yl)-4-aminoquinoline 1-oxide

Alkaline pH treatment of N-(deoxyguanosin-8-yl)-4-aminoquinoline 1-oxide forms two quinoline derivatives. The two compounds were analyzed together by mass and 500 MHz 1H-n.m.r. spectroscopies and were identified as two 7,8-guanine ring-opened rotamers: 1-(1' -deoxyriboside)-1-[6-(2,5-diamino-4-...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1985-02, Vol.6 (2), p.319-322
Main Authors: Bailleul, Bernard, Galiègue-Zouitina, Sylvie, Perly, Bruno, Loucheux-Lefebvre, Marie-Henriette
Format: Article
Language:English
Subjects:
Aminoquinolines
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Deoxyguanosine - analogs & derivatives
Hydrolysis
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Tumors
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Summary:Alkaline pH treatment of N-(deoxyguanosin-8-yl)-4-aminoquinoline 1-oxide forms two quinoline derivatives. The two compounds were analyzed together by mass and 500 MHz 1H-n.m.r. spectroscopies and were identified as two 7,8-guanine ring-opened rotamers: 1-(1' -deoxyriboside)-1-[6-(2,5-diamino-4-oxo-pyrimidinyl)]-3-(4-quinolinyl 1-oxide) urea.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/6.2.319