Prevention of hypovitaminosis D in the elderly

Conflicting opinions are held on the efficacy and safety of low-dose oral vitamin D supplementation. In this study, the value of short-term and long-term low-dose vitamin D supplementation (20 mu g D sub(3) daily) is demonstrated in elderly subjects. Short-term therapy readily restored serum 25-hydr...

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Bibliographic Details
Published in:Calcified tissue international 1985-03, Vol.37 (2), p.112-116
Main Authors: McKenna, M.J, Freaney, R, Meade, A, Muldowney, F.P
Format: Article
Language:English
Subjects:
Biological and medical sciences
calciferol
CARENCE EN VITAMINES
cholecalciferol
DEFICIENCIA DE VITAMINAS
geriatrics
LONGEVIDAD
LONGEVITE
LONGEVITY
man
Medical sciences
Miscellaneous
nutrient deficiency
Pharmacology. Drug treatments
PREVENCION
PREVENTION
TOXICIDAD
TOXICITE
TOXICITY
VITAMIN D
VITAMIN DEFICIENCIES
VITAMINA D
VITAMINE D
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Summary:Conflicting opinions are held on the efficacy and safety of low-dose oral vitamin D supplementation. In this study, the value of short-term and long-term low-dose vitamin D supplementation (20 mu g D sub(3) daily) is demonstrated in elderly subjects. Short-term therapy readily restored serum 25-hydroxy-vitamin D (25OHD) values to normal, and ameliorated biochemical abnormalities of calcium, phosphate, and alkaline phosphatase, consistent with healing of mild osteomalacia. Prolonged therapy (16 months) maintained serum 25OHD levels within the young adult range, and was not associated with hypercalcemia. Withdrawal of therapy was associated with a steady decline in serum 25OHD levels. Low-dose vitamin D supplementation is recommended for elderly subjects to prevent the development of hypovitaminosis D osteopathy.
ISSN:0171-967X
1432-0827
DOI:10.1007/BF02554828