90-Day oral toxicity of ziram: a thyrostatic and hepatotoxic study

Ziram, a dithiocarbamate fungicide, is extensively used in crop protection. Daily oral doses of ziram (5 and 25 mg kg −1 day −1) for 30, 60 and 90 days produced significant mortality in male rats. The fungicide also caused a significant increase in the thyroid:body weight ratio, histological changes...

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Bibliographic Details
Published in:Environmental pollution (1987) 1990, Vol.65 (4), p.311-322
Main Authors: Pandey, Mamta, Raizada, R.B., Dikshith, T.S.S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
blood serum
body weight
brain
enzyme activity
histology
liver
Medical sciences
mortality
Pesticides, fertilizers and other agrochemicals toxicology
rats
thyroid function
thyroid gland
toxicity
Toxicology
ziram
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Summary:Ziram, a dithiocarbamate fungicide, is extensively used in crop protection. Daily oral doses of ziram (5 and 25 mg kg −1 day −1) for 30, 60 and 90 days produced significant mortality in male rats. The fungicide also caused a significant increase in the thyroid:body weight ratio, histological changes, and a reduced activity of thyroid 1 25I uptake and protein bound 1 25I. However, the animals did not show any change in the clinical enzyme profile of the liver, serum and brain. It is believed that ETU, the degradation product of ziram and a known antithyroid compound, is the causative agent for the high mortality, as well as for the pronounced thyrostatic and hepatotoxic effects found in the experimental animals.
ISSN:0269-7491
1873-6424
DOI:10.1016/0269-7491(90)90123-T