Effect of Hypogammaglobulinemia on the Incidence of Community-Acquired Respiratory Viral Infections After Lung Transplantation

Abstract Background Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipi...

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Bibliographic Details
Published in:Transplantation proceedings 2013-07, Vol.45 (6), p.2371-2374
Main Authors: Noell, B.C, Dawson, K.L, Seethamraju, H
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Common Variable Immunodeficiency - diagnosis
Common Variable Immunodeficiency - epidemiology
Common Variable Immunodeficiency - mortality
Community-Acquired Infections - diagnosis
Community-Acquired Infections - epidemiology
Community-Acquired Infections - mortality
Community-Acquired Infections - virology
Female
Forced Expiratory Volume
Graft Rejection - epidemiology
Humans
Immunoglobulin G - blood
Incidence
Kaplan-Meier Estimate
Lung - physiopathology
Lung - virology
Lung Transplantation - adverse effects
Lung Transplantation - mortality
Male
Middle Aged
Respiratory Function Tests
Respiratory Tract Infections - diagnosis
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - mortality
Respiratory Tract Infections - virology
Retrospective Studies
Risk Factors
Surgery
Texas - epidemiology
Time Factors
Treatment Outcome
Virus Diseases - diagnosis
Virus Diseases - epidemiology
Virus Diseases - mortality
Virus Diseases - virology
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Summary:Abstract Background Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipients with HGG are at an increased risk of developing CARV infection. Secondary endpoints included the effect of HGG on lung function, incidence of rejection, and mortality. Methods A retrospective review of all lung transplant recipients from 2008 to 2011 was performed. Patients were stratified as either having HGG after transplantation or having normal IgG titers according to their nadir IgG level. HGG was defined a serum IgG level of
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2012.11.010