Relationship between IL-10 gene −1082A/G and −592C/A polymorphisms and the risk of hepatitis C infection: a meta-analysis

• Published in: Journal of viral hepatitis 2013-09, Vol.20 (9), p.602-611
• Main Authors: Sun, X.-R., Wu, J., Shi, K.-Q., Tang, K.-F.
• Format: Article
• Language: English
• Subjects: chronic hepatitis C; Disease Resistance; Genetic Predisposition to Disease; Hepatitis C - genetics; Hepatitis C virus; Humans; IL-10 gene; Interleukin-10 - genetics; meta-analysis; polymorphism; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Assessment
• ISSN: 1352-0504; 1365-2893
• DOI: 10.1111/jvh.12082

Summary Increasing evidence suggests that interleukin‐10 (IL‐10) gene promoter polymorphisms may be associated with chronic hepatitis C virus (HCV) infection and HCV clearance. To more precisely estimate the association between these variants and the risk of HCV infection, we performed a meta‐analysis of 26 studies describing the IL‐10–1082A/G, –819C/T, –592C/A genotypes, including 4039 chronic HCV infection cases and 2902 controls. When compared with a healthy population, the –1082GG allele had a 43% increased risk of chronic HCV infection in combined populations (GG vs GA + AA: odds ratio (OR) = 1.433, 95% confidence interval (CI) = 1.052–1.952, P = 0.023). In subgroup analysis by ethnicity, a significant increased risk was associated with the −1082GG genotype in the Caucasian population (GG vs AA: OR = 1.390, 95% CI: 1.108–1.744, P = 0.004; GG vs GA + AA: OR = 1.621, 95% CI: 1.267–2.075, P = 0.000). However, no significant association was found in Asian, African or Chinese populations. Moreover, a higher distribution of −592A was found in the spontaneously recovered population (AA vs CC: OR = 0.585, 95% CI = 0.387–0.884, P = 0.011; AA + AC vs CC: OR = 0.738, 95% CI = 0.551–0.988, P = 0.041; AA vs AC + CC: OR = 0.788, 95% CI = 0.664–0.935, P = 0.006) than that in the chronic HCV infection population. In conclusion, the IL‐10–1082GG allele may increase the risk of chronic HCV infection in Caucasian population, and people carrying the IL‐10–592A allele are more likely to clear HCV spontaneously.