Nalbuphine antagonism of ventilatory depression following high-dose fentanyl anesthesia

Prolonged respiratory depression requiring overnight mechanical ventilation may follow the use of large doses of fentanyl for anesthesia. However, patients with stable cardiovascular and pulmonary function have been extubated within 8 h of aortocoronary bypass (ACB) surgery without significant morbi...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1985-05, Vol.62 (5), p.647-650
Main Authors: MOLDENHAUER, C. C, ROACH, G. W, FINLAYSON, D. C, HUG, C. C. JR, KOPEL, M. E, TOBIA, V, KELLY, S
Format: Article
Language:English
Subjects:
Aged
Anesthesia, General
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Carbon Dioxide - blood
Female
Fentanyl - adverse effects
Fentanyl - antagonists & inhibitors
Hemodynamics - drug effects
Humans
Male
Medical sciences
Middle Aged
Morphinans - therapeutic use
Nalbuphine - adverse effects
Nalbuphine - therapeutic use
Neuropharmacology
Pain, Postoperative - drug therapy
Pharmacology. Drug treatments
Postoperative Period
Respiration - drug effects
Respiration, Artificial
Time Factors
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Summary:Prolonged respiratory depression requiring overnight mechanical ventilation may follow the use of large doses of fentanyl for anesthesia. However, patients with stable cardiovascular and pulmonary function have been extubated within 8 h of aortocoronary bypass (ACB) surgery without significant morbidity or mortality. Early extubation may improve patient comfort, decrease requirements for sedative drugs, and reduce intensive care unit (ICU) time and hospital costs. In two recent studies, nalbuphine antagonized respiratory depression induced by moderate doses of narcotic analgesics administered during general anesthesia for noncardiac surgery. No significant adverse consequences were reported. The authors' study evaluated the safety and efficacy of nalbuphine in antagonizing ventilatory depression following high-dose fentanyl anesthesia for ACB surgery.
ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-198505000-00021