Effect of Surface Compositional Heterogeneities and Microphase Segregation of Fluorinated Amphiphilic Copolymers on Antifouling Performance

In this paper, a series of fluorinated amphiphilic copolymers composed of 2-perfluorooctylethyl methacrylate (FMA) and 2-hydroxyethyl methacrylate (HEMA) monomers were prepared, and their surface properties and antifouling performance were investigated. Bovine serum albumin (BSA) and human plasma fi...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2013-08, Vol.5 (16), p.7808-7818
Main Authors: Zhao, Zeliang, Ni, Huagang, Han, Zhiyuan, Jiang, Tengfei, Xu, Yongjuan, Lu, Xiaolin, Ye, Peng
Format: Article
Language:English
Subjects:
Adsorption
Fibrinogen - chemistry
Halogenation
Humans
Hydrophobic and Hydrophilic Interactions
Methacrylates - chemistry
Photoelectron Spectroscopy
Polymers - chemistry
Serum Albumin, Bovine - chemistry
Surface Properties
Surface-Active Agents - chemistry
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Summary:In this paper, a series of fluorinated amphiphilic copolymers composed of 2-perfluorooctylethyl methacrylate (FMA) and 2-hydroxyethyl methacrylate (HEMA) monomers were prepared, and their surface properties and antifouling performance were investigated. Bovine serum albumin (BSA) and human plasma fibrinogen (HFg) were used as model proteins to study protein adsorption onto the fluorinated amphiphilic surfaces. All the fluorinated amphiphilic surfaces exhibit excellent resistant performance of protein adsorption measured by X-ray photoelectron spectroscopy (XPS). The surface compositional heterogeneities on the molecular scale play an important role in the antifouling properties. It was found that the copolymers exhibited better antifouling properties than the corresponding homopolymers did, when the percentage of hydrophilic hydroxyl groups is from 4% to 7% and the percentage of hydrophobic fluorinated moieties is from 4% to 14% on the surface. In addition, the protein molecular size scale and the pattern of microphase segregation domains on the surface strongly affect the protein adsorption behaviors. These results demonstrate the desirable protein-resistant performance from the fluorinated amphiphilic copolymers and provide deeper insight of the effect of surface compositional heterogeneity and microphase segregation on the protein adsorption behaviors.
ISSN:1944-8244
1944-8252
DOI:10.1021/am401568b