DNA copy gains of tumor-related genes in vestibular schwannoma

DNA copy gains are a common event in tumor growth. This study determines the gene dosage/amplification of seven tumor-related genes in patients undergoing vestibular schwannoma (VS) surgery and analyzes its clinical implications. Thirty-three patients undergoing surgery for VS were studied. Seven ge...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2013-09, Vol.270 (9), p.2433-2438
Main Authors: Lassaletta, Luis, Torres-Martín, Miguel, San-Román-Montero, Jesús, Castresana, Javier S., Gavilán, Javier, Rey, Juan Antonio
Format: Article
Language:English
Subjects:
Adult
Cranial Nerve Neoplasms - genetics
Female
Gene Amplification
Gene Dosage
Gene Expression Regulation, Neoplastic
Genes, erbB-2
Head and Neck Surgery
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroma, Acoustic - genetics
Neurosurgery
Otology
Otorhinolaryngology
Proto-Oncogenes
Real-Time Polymerase Chain Reaction
Tumor Burden
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Summary:DNA copy gains are a common event in tumor growth. This study determines the gene dosage/amplification of seven tumor-related genes in patients undergoing vestibular schwannoma (VS) surgery and analyzes its clinical implications. Thirty-three patients undergoing surgery for VS were studied. Seven genes ( EGFR, ERBB2, ERBB3, ERBB4, MDM2, MDM4 , and NMYC ) were analyzed by Quantitative real-time PCR. Copy gains were correlated with demographic, clinical and radiological data. Of the 33 samples, 48 % were positive for copy gains in at least one gene. There were no positive samples for gene amplification. A clinical correlation between tumor size and copy gains of ERBB2 was found. Patients with copy gains of this gene had larger tumors measured by diameter ( p  = 0.027) and volume ( p  = 0.005). Copy gains of EGFR , ERBB2 , ERBB4 , and MDM4 were associated with preoperative tinnitus. Contrary to other tumors of the central nervous system, development of VS does not appear to involve gene amplification. However, copy gains of certain tumor-related genes may play a role in the biological behavior of these neoplasms. Our findings support the role of ERBB2 in VS development and growth
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-012-2269-z