Serum markers of collagen synthesis and degradation in acute respiratory failure patients

Background Procollagen‐derived propeptides reflect the rate of collagen synthesis and type I cross‐linked collagen telopeptides (ICTP) collagen I degradation. We studied the collagen metabolism to find out if changes seen in acute respiratory distress syndrome patients are observed in patients with...

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Published in:Acta anaesthesiologica Scandinavica 2013-10, Vol.57 (9), p.1193-1200
Main Authors: OKKONEN, M., GÄDDNÄS, F., PETTILÄ, V., LAURILA, J., OHTONEN, P., RISTELI, J., LINKO, R., ALA-KOKKO, T.
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Aged, 80 and over
Cohort Studies
Collagen - biosynthesis
Critical Care
Female
Humans
Length of Stay
Male
Middle Aged
Multiple Organ Failure - metabolism
Peptide Fragments - metabolism
Procollagen - metabolism
Prospective Studies
Respiratory diseases
Respiratory distress syndrome
Respiratory Insufficiency - metabolism
Respiratory therapy
Wound healing
Young Adult
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Summary:Background Procollagen‐derived propeptides reflect the rate of collagen synthesis and type I cross‐linked collagen telopeptides (ICTP) collagen I degradation. We studied the collagen metabolism to find out if changes seen in acute respiratory distress syndrome patients are observed in patients with acute respiratory failure (ARF), and whether multiple organ dysfunction (MOD) has impact on it. Methods ARF patients with prolonged hospitalisation at least 21 days were included to the study. Blood samples for serum procollagen aminoterminal propeptide I (PINP) and III (PIIINP), and ICTP measurements were collected at study admission (day 0) and on days 2, 7, and 21. Results The study population comprised 68 patients. Forty‐three patients (63%) developed MOD during the first week. PIIINP levels increased in all patients over time. The increase was slightly more pronounced in patients with MOD. During the first week, the synthesis of PIIINP increased more than PINP, and PINP degradation exceeded its production. By day 21, the balance of collagen metabolites returned to baseline. Conclusion The collagen metabolism was altered in ARF patients. The first week was dominated by degradation of type I collagen and production of type III collagen, but by day 21, the collagen composition returned to more stable form.
ISSN:0001-5172
1399-6576
DOI:10.1111/aas.12182