Predicting drug―target interactions from chemical and genomic kernels using Bayesian matrix factorization

• Published in: Bioinformatics 2012-09, Vol.28 (18), p.2304-2310
• Main Author: GONEN, Mehmet
• Format: Article
• Language: English
• Subjects: Algorithms; Bayes Theorem; Biological and medical sciences; Drug Discovery; Enzymes - drug effects; Fundamental and applied biological sciences. Psychology; General aspects; Genomics; Humans; Ion Channels - drug effects; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Pharmaceutical Preparations - chemistry; Proteins - chemistry; Proteins - drug effects; Proteins - genetics; Receptors, Cytoplasmic and Nuclear - drug effects; Receptors, G-Protein-Coupled - drug effects; Sequence Analysis, Protein
• ISSN: 1367-4803; 1367-4811; 1460-2059
• DOI: 10.1093/bioinformatics/bts360

Identifying interactions between drug compounds and target proteins has a great practical importance in the drug discovery process for known diseases. Existing databases contain very few experimentally validated drug-target interactions and formulating successful computational methods for predicting interactions remains challenging. In this study, we consider four different drug-target interaction networks from humans involving enzymes, ion channels, G-protein-coupled receptors and nuclear receptors. We then propose a novel Bayesian formulation that combines dimensionality reduction, matrix factorization and binary classification for predicting drug-target interaction networks using only chemical similarity between drug compounds and genomic similarity between target proteins. The novelty of our approach comes from the joint Bayesian formulation of projecting drug compounds and target proteins into a unified subspace using the similarities and estimating the interaction network in that subspace. We propose using a variational approximation in order to obtain an efficient inference scheme and give its detailed derivations. Finally, we demonstrate the performance of our proposed method in three different scenarios: (i) exploratory data analysis using low-dimensional projections, (ii) predicting interactions for the out-of-sample drug compounds and (iii) predicting unknown interactions of the given network. Software and Supplementary Material are available at http://users.ics.aalto.fi/gonen/kbmf2k. [e-mail] Supplementary data are available at Bioinformatics online.