Loading…
Bone marrow stimulation of the medial femoral condyle produces inferior cartilage and bone repair compared to the trochlea in a rabbit surgical model
ABSTRACT The influence of the location of cartilage lesions on cartilage repair outcome is incompletely understood. This study compared cartilage and bone repair in medial femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation in mature rabbits. Intact fe...
Saved in:
| Published in: | Journal of orthopaedic research 2013-11, Vol.31 (11), p.1757-1764 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3982-fa51baec9bafb13288474a427c968611bfde69b59ed1b7f633e64419c10699773 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3982-fa51baec9bafb13288474a427c968611bfde69b59ed1b7f633e64419c10699773 |
| container_end_page | 1764 |
| container_issue | 11 |
| container_start_page | 1757 |
| container_title | Journal of orthopaedic research |
| container_volume | 31 |
| creator | Chen, Hongmei Chevrier, Anik Hoemann, Caroline D. Sun, Jun Picard, Genevieve Buschmann, Michael D. |
| description | ABSTRACT
The influence of the location of cartilage lesions on cartilage repair outcome is incompletely understood. This study compared cartilage and bone repair in medial femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation in mature rabbits. Intact femurs from adult rabbits served as controls. Results from quantitative histomorphometry and histological scoring showed that bone marrow stimulation produced inferior soft tissue repair in MFC versus TR defects, as indicated by significantly lower % Fill (p = 0.03), a significant increase in collagen type I immunostaining (p |
| doi_str_mv | 10.1002/jor.22422 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1438573123</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1438573123</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3982-fa51baec9bafb13288474a427c968611bfde69b59ed1b7f633e64419c10699773</originalsourceid><addsrcrecordid>eNp1kctu1DAUhi0EokNhwQsgL2GR1rfYyRJGUEBVK3HRsLNs56R1ceKp7ajMg_C-uJ22O1Zncb7_s_wfhF5TckQJYcdXMR0xJhh7gla0bUXTMvXrKVoRxWVDmJQH6EXOV4QQRVn3HB0w3glOFVuhvx_iDHgyKcUbnIuflmCKjzOOIy6XdQODNwGPMMVUp4vzsAuAtykOi4OM_TxC8jFhZ1LxwVwANvOA7a01wdb4uonT1iQYcIl3ypKiuwxgahYbnIy1vuC8pAvv6gtTHCC8RM9GEzK8up-H6Oenjz_Wn5vT85Mv6_enjeN9x5rRtNQacL01o6WcdZ1QwgimXC87SakdB5C9bXsYqFWj5BykELR3lMi-V4oford7b_3P9QK56MlnByGYGeKSNRW8axWnjFf03R51KeacYNTb5GtvO02Jvr2CrlfQd1eo7Jt77WJrgY_kQ-0VON4DNz7A7v8m_fX824Oy2Sd8LvDnMWHSby0VV63enJ3os813RTdkrSn_B6qsosg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1438573123</pqid></control><display><type>article</type><title>Bone marrow stimulation of the medial femoral condyle produces inferior cartilage and bone repair compared to the trochlea in a rabbit surgical model</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Chen, Hongmei ; Chevrier, Anik ; Hoemann, Caroline D. ; Sun, Jun ; Picard, Genevieve ; Buschmann, Michael D.</creator><creatorcontrib>Chen, Hongmei ; Chevrier, Anik ; Hoemann, Caroline D. ; Sun, Jun ; Picard, Genevieve ; Buschmann, Michael D.</creatorcontrib><description>ABSTRACT
The influence of the location of cartilage lesions on cartilage repair outcome is incompletely understood. This study compared cartilage and bone repair in medial femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation in mature rabbits. Intact femurs from adult rabbits served as controls. Results from quantitative histomorphometry and histological scoring showed that bone marrow stimulation produced inferior soft tissue repair in MFC versus TR defects, as indicated by significantly lower % Fill (p = 0.03), a significant increase in collagen type I immunostaining (p < 0.00001) and lower O'Driscoll scores (p < 0.05). 3D micro‐CT analysis showed that repaired TR defects regained normal un‐operated values of bone volume fraction, trabecular thickness, and trabecular number, whereas in MFC defects the repaired bone architecture appeared immature and less dense compared to intact un‐operated MFC controls (p < 0.0001). Severe medial meniscal damage was found in 28% of operated animals and was strongly correlated with (i) low cartilage defect fill, (ii) incomplete bone repair in MFC, and (iii) with a more posterior defect placement in the weight‐bearing region. We conclude that the location of cartilage lesions influences cartilage repair, with better outcome in TR versus MFC defects in rabbits. Meniscal degeneration is associated with cartilage damage. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1757–1764, 2013</description><identifier>ISSN: 0736-0266</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1002/jor.22422</identifier><identifier>PMID: 23843172</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Bone Marrow - physiology ; bone marrow stimulation ; cartilage repair ; Cartilage, Articular - physiopathology ; Cartilage, Articular - surgery ; Female ; Femur - pathology ; Femur - physiopathology ; Femur - surgery ; medial femoral condyle ; Menisci, Tibial - pathology ; meniscus degeneration ; Models, Anatomic ; Models, Animal ; Rabbits ; trochlea ; Wound Healing ; X-Ray Microtomography</subject><ispartof>Journal of orthopaedic research, 2013-11, Vol.31 (11), p.1757-1764</ispartof><rights>2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3982-fa51baec9bafb13288474a427c968611bfde69b59ed1b7f633e64419c10699773</citedby><cites>FETCH-LOGICAL-c3982-fa51baec9bafb13288474a427c968611bfde69b59ed1b7f633e64419c10699773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23843172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hongmei</creatorcontrib><creatorcontrib>Chevrier, Anik</creatorcontrib><creatorcontrib>Hoemann, Caroline D.</creatorcontrib><creatorcontrib>Sun, Jun</creatorcontrib><creatorcontrib>Picard, Genevieve</creatorcontrib><creatorcontrib>Buschmann, Michael D.</creatorcontrib><title>Bone marrow stimulation of the medial femoral condyle produces inferior cartilage and bone repair compared to the trochlea in a rabbit surgical model</title><title>Journal of orthopaedic research</title><addtitle>J. Orthop. Res</addtitle><description>ABSTRACT
The influence of the location of cartilage lesions on cartilage repair outcome is incompletely understood. This study compared cartilage and bone repair in medial femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation in mature rabbits. Intact femurs from adult rabbits served as controls. Results from quantitative histomorphometry and histological scoring showed that bone marrow stimulation produced inferior soft tissue repair in MFC versus TR defects, as indicated by significantly lower % Fill (p = 0.03), a significant increase in collagen type I immunostaining (p < 0.00001) and lower O'Driscoll scores (p < 0.05). 3D micro‐CT analysis showed that repaired TR defects regained normal un‐operated values of bone volume fraction, trabecular thickness, and trabecular number, whereas in MFC defects the repaired bone architecture appeared immature and less dense compared to intact un‐operated MFC controls (p < 0.0001). Severe medial meniscal damage was found in 28% of operated animals and was strongly correlated with (i) low cartilage defect fill, (ii) incomplete bone repair in MFC, and (iii) with a more posterior defect placement in the weight‐bearing region. We conclude that the location of cartilage lesions influences cartilage repair, with better outcome in TR versus MFC defects in rabbits. Meniscal degeneration is associated with cartilage damage. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1757–1764, 2013</description><subject>Animals</subject><subject>Bone Marrow - physiology</subject><subject>bone marrow stimulation</subject><subject>cartilage repair</subject><subject>Cartilage, Articular - physiopathology</subject><subject>Cartilage, Articular - surgery</subject><subject>Female</subject><subject>Femur - pathology</subject><subject>Femur - physiopathology</subject><subject>Femur - surgery</subject><subject>medial femoral condyle</subject><subject>Menisci, Tibial - pathology</subject><subject>meniscus degeneration</subject><subject>Models, Anatomic</subject><subject>Models, Animal</subject><subject>Rabbits</subject><subject>trochlea</subject><subject>Wound Healing</subject><subject>X-Ray Microtomography</subject><issn>0736-0266</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kctu1DAUhi0EokNhwQsgL2GR1rfYyRJGUEBVK3HRsLNs56R1ceKp7ajMg_C-uJ22O1Zncb7_s_wfhF5TckQJYcdXMR0xJhh7gla0bUXTMvXrKVoRxWVDmJQH6EXOV4QQRVn3HB0w3glOFVuhvx_iDHgyKcUbnIuflmCKjzOOIy6XdQODNwGPMMVUp4vzsAuAtykOi4OM_TxC8jFhZ1LxwVwANvOA7a01wdb4uonT1iQYcIl3ypKiuwxgahYbnIy1vuC8pAvv6gtTHCC8RM9GEzK8up-H6Oenjz_Wn5vT85Mv6_enjeN9x5rRtNQacL01o6WcdZ1QwgimXC87SakdB5C9bXsYqFWj5BykELR3lMi-V4oford7b_3P9QK56MlnByGYGeKSNRW8axWnjFf03R51KeacYNTb5GtvO02Jvr2CrlfQd1eo7Jt77WJrgY_kQ-0VON4DNz7A7v8m_fX824Oy2Sd8LvDnMWHSby0VV63enJ3os813RTdkrSn_B6qsosg</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Chen, Hongmei</creator><creator>Chevrier, Anik</creator><creator>Hoemann, Caroline D.</creator><creator>Sun, Jun</creator><creator>Picard, Genevieve</creator><creator>Buschmann, Michael D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Bone marrow stimulation of the medial femoral condyle produces inferior cartilage and bone repair compared to the trochlea in a rabbit surgical model</title><author>Chen, Hongmei ; Chevrier, Anik ; Hoemann, Caroline D. ; Sun, Jun ; Picard, Genevieve ; Buschmann, Michael D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3982-fa51baec9bafb13288474a427c968611bfde69b59ed1b7f633e64419c10699773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Bone Marrow - physiology</topic><topic>bone marrow stimulation</topic><topic>cartilage repair</topic><topic>Cartilage, Articular - physiopathology</topic><topic>Cartilage, Articular - surgery</topic><topic>Female</topic><topic>Femur - pathology</topic><topic>Femur - physiopathology</topic><topic>Femur - surgery</topic><topic>medial femoral condyle</topic><topic>Menisci, Tibial - pathology</topic><topic>meniscus degeneration</topic><topic>Models, Anatomic</topic><topic>Models, Animal</topic><topic>Rabbits</topic><topic>trochlea</topic><topic>Wound Healing</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hongmei</creatorcontrib><creatorcontrib>Chevrier, Anik</creatorcontrib><creatorcontrib>Hoemann, Caroline D.</creatorcontrib><creatorcontrib>Sun, Jun</creatorcontrib><creatorcontrib>Picard, Genevieve</creatorcontrib><creatorcontrib>Buschmann, Michael D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hongmei</au><au>Chevrier, Anik</au><au>Hoemann, Caroline D.</au><au>Sun, Jun</au><au>Picard, Genevieve</au><au>Buschmann, Michael D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone marrow stimulation of the medial femoral condyle produces inferior cartilage and bone repair compared to the trochlea in a rabbit surgical model</atitle><jtitle>Journal of orthopaedic research</jtitle><addtitle>J. Orthop. Res</addtitle><date>2013-11</date><risdate>2013</risdate><volume>31</volume><issue>11</issue><spage>1757</spage><epage>1764</epage><pages>1757-1764</pages><issn>0736-0266</issn><eissn>1554-527X</eissn><abstract>ABSTRACT
The influence of the location of cartilage lesions on cartilage repair outcome is incompletely understood. This study compared cartilage and bone repair in medial femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation in mature rabbits. Intact femurs from adult rabbits served as controls. Results from quantitative histomorphometry and histological scoring showed that bone marrow stimulation produced inferior soft tissue repair in MFC versus TR defects, as indicated by significantly lower % Fill (p = 0.03), a significant increase in collagen type I immunostaining (p < 0.00001) and lower O'Driscoll scores (p < 0.05). 3D micro‐CT analysis showed that repaired TR defects regained normal un‐operated values of bone volume fraction, trabecular thickness, and trabecular number, whereas in MFC defects the repaired bone architecture appeared immature and less dense compared to intact un‐operated MFC controls (p < 0.0001). Severe medial meniscal damage was found in 28% of operated animals and was strongly correlated with (i) low cartilage defect fill, (ii) incomplete bone repair in MFC, and (iii) with a more posterior defect placement in the weight‐bearing region. We conclude that the location of cartilage lesions influences cartilage repair, with better outcome in TR versus MFC defects in rabbits. Meniscal degeneration is associated with cartilage damage. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1757–1764, 2013</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23843172</pmid><doi>10.1002/jor.22422</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0736-0266 |
| ispartof | Journal of orthopaedic research, 2013-11, Vol.31 (11), p.1757-1764 |
| issn | 0736-0266 1554-527X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1438573123 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals Bone Marrow - physiology bone marrow stimulation cartilage repair Cartilage, Articular - physiopathology Cartilage, Articular - surgery Female Femur - pathology Femur - physiopathology Femur - surgery medial femoral condyle Menisci, Tibial - pathology meniscus degeneration Models, Anatomic Models, Animal Rabbits trochlea Wound Healing X-Ray Microtomography |
| title | Bone marrow stimulation of the medial femoral condyle produces inferior cartilage and bone repair compared to the trochlea in a rabbit surgical model |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T21%3A09%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bone%20marrow%20stimulation%20of%20the%20medial%20femoral%20condyle%20produces%20inferior%20cartilage%20and%20bone%20repair%20compared%20to%20the%20trochlea%20in%20a%20rabbit%20surgical%20model&rft.jtitle=Journal%20of%20orthopaedic%20research&rft.au=Chen,%20Hongmei&rft.date=2013-11&rft.volume=31&rft.issue=11&rft.spage=1757&rft.epage=1764&rft.pages=1757-1764&rft.issn=0736-0266&rft.eissn=1554-527X&rft_id=info:doi/10.1002/jor.22422&rft_dat=%3Cproquest_cross%3E1438573123%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3982-fa51baec9bafb13288474a427c968611bfde69b59ed1b7f633e64419c10699773%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1438573123&rft_id=info:pmid/23843172&rfr_iscdi=true |