Immunopathological study of parasitic cholangitis in cetaceans

This paper describes the immunophenotype of cellular inflammatory infiltrates in chronic cholangitis in six common dolphins (Delphinus delphis), four striped dolphins (Stenella coeruleoalba), three Atlantic spotted dolphins (Stenella frontalis) and one pygmy sperm whale (Kogia Breviceps) found stran...

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Bibliographic Details
Published in:Research in veterinary science 2013-10, Vol.95 (2), p.556-561
Main Authors: Jaber, J.R., Zafra, R., Pérez, J., Suárez-Bonnet, A., González, J.F., Carrascosa, C., Andrada, M., Arbelo, M., Fernández, A.
Format: Article
Language:English
Subjects:
Animals
antibodies
Antibodies, Helminth - blood
antigens
bile ducts
Cetacea
Cholangitis
Cholangitis - parasitology
Cholangitis - veterinary
coasts
cortex
cross reaction
Delphinus
Dolphins
eggs
Immune system
Immunology
inducible nitric oxide synthase
Infections
Liver
Liver - parasitology
Liver - pathology
lymph nodes
Lymphocytes
macrophages
Marine
Marine mammals
Methods
Parasites
Pathology
Physeter macrocephalus
Plasma
Stenella coeruleoalba
Trematoda - classification
Trematode Infections - parasitology
Trematode Infections - pathology
Trematode Infections - veterinary
Veterinary medicine
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Summary:This paper describes the immunophenotype of cellular inflammatory infiltrates in chronic cholangitis in six common dolphins (Delphinus delphis), four striped dolphins (Stenella coeruleoalba), three Atlantic spotted dolphins (Stenella frontalis) and one pygmy sperm whale (Kogia Breviceps) found stranded along the coasts of the Canary Islands (Spain). A panel of 5 antibodies previously tested in dolphins (anti-CD3, -IgG, -MHC class II, -S100 protein and -lysozyme) were used. The present work also reports cross reactivity with dolphin antigens of two antibodies not used to date in dolphins (anti-mouse iNOS and anti-mouse Foxp3). The most common type of cholangitis found was chronic granulomatous cholangitis, associated with the presence of the parasite Campula spp., or its eggs in bile ducts. The cellular composition of the hepatic inflammatory infiltrate associated to chronic parasitic cholangitis was closely similar to that found in the cortex of control lymph nodes, including the presence of S100+ and MHC class II+ dendritic-like cells in lymphoid follicles and interfollicular areas. Only occasional macrophages expressed iNOS, whereas Foxp3+ lymphocytes were not found in any of the lesions described in the different types of cholangitis.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2013.05.011