Periosteal Adventitia is a Valuable Bone Graft Alternative

Background Periosteal adventitia is believed to consist of fibrous tissue without any regenerative potential. This theory results in the assumption that surgically stripped periosteum which is also adventitial has no bone regeneration potential. We decided to test whether the periosteal adventitia i...

Full description

Saved in:
Bibliographic Details
Published in:International journal of artificial organs 2013-05, Vol.36 (5), p.341-349
Main Authors: Gemalmaz, Halil Can, Bolukbasi, Selcuk, Esen, Erdinc, Erdogan, Deniz, Giray, Seren Gulsen, Bardakci, Yesim
Format: Article
Language:English
Subjects:
Adventitia - transplantation
Animal models
Animals
Bone Regeneration
Bone Substitutes - pharmacology
Bone Transplantation - methods
Female
Femur - pathology
Femur - physiopathology
Femur - surgery
Male
Models, Animal
Osteotomy
Periosteum - transplantation
Rabbits
Time Factors
Transplantation, Autologous
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Periosteal adventitia is believed to consist of fibrous tissue without any regenerative potential. This theory results in the assumption that surgically stripped periosteum which is also adventitial has no bone regeneration potential. We decided to test whether the periosteal adventitia is osteoinductive and whether it is suitable for a commonly faced clinical situation in an animal model. Methods This study used 24 femurs from 12 rabbits, which were separated into 3 groups. Lateral femoral condylar cavitary defects were created with a 5 mm drill bit. In group I, the defects were left empty as the control. In group II, the defects were only filled with ceramic graft particles. In group III, the defects were filled with a mixture of ceramic graft particles and autogenous, adventitial, periosteal particles. All animals were sacrificed at the end of the 6th week and were evaluated histologically. Results The microscopy of 3 different histologists suggested that group III had far superior healing when compared to the control group and group II. The statistical evaluation of the histomorphometrically gathered quantitative results revealed a meaningful increase in woven bone and a decrease in fibrous tissue in group III, confirming the histological analysis. Conclusions In this study we observed that the composite graft obtained by mixing ceramics and free adventitial periosteal grafts offers healing potential surpassing both the ceramic-only group as well as the control group. We conclude that adventitial periosteal graft greatly facilitates new bone formation.
ISSN:0391-3988
1724-6040
DOI:10.5301/ijao.5000228