Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants

• Published in: Gene 2013-11, Vol.531 (1), p.71-77
• Main Authors: Ye, Huadan, Li, Xiaojing, Wang, Lingyan, Liao, Qi, Xu, Leiting, Huang, Yi, Xu, Liming, Xu, Xuting, Chen, Cheng, Wu, Hangyu, Le, Yanping, Liu, Qiong, Ye, Meng, Dong, Changzheng, Duan, Shiwei
• Format: Article
• Language: English
• Subjects: Coronary Artery Disease - genetics; Coronary Disease - genetics; Coronary heart disease; Genetic Association Studies; Genetic Variation; GPX1; Humans; Meta-analysis; Odds Ratio; Polymorphism; Polymorphism, Single Nucleotide
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2013.07.029

The aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD). Through a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012). A total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1 rs1050450 polymorphism and CHD (odd ratio (OR)=1.61, 95% confidence interval (CI)=1.25–2.07, P=0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD. Our results confirmed that GPX1 rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations. •Our meta-analyses are involved with 12 variants.•Our meta-analyses are involved with 23,314 cases and 28,430 controls.•Meta-analysis among 2538 samples confirmed GPX1 rs1050450 as a CHD risk factor.