Regression of the inflammatory microenvironment of the peritoneal cavity in women with endometriosis by GnRHa treatment

Abstract Objective To investigate the effect of gonadotropin-releasing hormone analogues (GnRHa) on the peritoneal fluid microenvironment in women with endometriosis. Study design Peritoneal fluid was collected from 85 women with severe endometriosis (rAFS stage III and IV) during laparoscopic surge...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2013-10, Vol.170 (2), p.550-554
Main Authors: Nirgianakis, K, Bersinger, N.A, McKinnon, B, Kostov, P, Imboden, S, Mueller, M.D
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Agents, Hormonal - pharmacology
Antineoplastic Agents, Hormonal - therapeutic use
Ascitic Fluid - pathology
Case-Control Studies
Cytokines
Cytokines - antagonists & inhibitors
Cytokines - biosynthesis
Cytokines - blood
Endometriosis
Endometriosis - drug therapy
Endometriosis - pathology
Endometriosis - surgery
Female
GnRH agonists
Gonadotropin-Releasing Hormone - agonists
Gonadotropin-Releasing Hormone - therapeutic use
Goserelin - pharmacology
Goserelin - therapeutic use
Humans
Inflammation - metabolism
Inflammation - pathology
Inflammation - prevention & control
Obstetrics and Gynecology
Peritoneal fluid
Up-Regulation - physiology
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Summary:Abstract Objective To investigate the effect of gonadotropin-releasing hormone analogues (GnRHa) on the peritoneal fluid microenvironment in women with endometriosis. Study design Peritoneal fluid was collected from 85 women with severe endometriosis (rAFS stage III and IV) during laparoscopic surgery during the proliferative phase. Prior to surgery clinical data were collected. The concentrations of specific markers for endometriosis in the peritoneal fluid were determined using an ELISA and a comparison between peritoneal fluid markers in women using GnRHa and no hormonal treatment was performed using a non-parametric Mann–Whitney U test. Results The study included peritoneal fluid from 39 patients who had been administered GnRHa (Zoladex® ) in the three months prior to surgery and 46 from women with no hormonal treatment in this period. Concentrations of IL-8, PAPP-A, glycodelin-A and midkine were significantly reduced in the GnRHa treatment group compared to women receiving no hormonal treatment. RANTES, MCP-1, ENA-78, TNF-α, OPG, IP-10 and defensin showed no significant change between the two groups. Conclusions GnRHa mediate a significant regression in the inflammatory nature of the peritoneal microenvironment in women with endometriosis.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2013.08.010