Psychiatric co-morbidities in patients with chronic peripheral neuropathic pain: A multicentre cohort study

Background Psychiatric co‐morbidities are common in patients with chronic pain, but no data are available about their prevalence in patients with neuropathic pain. Methods A multicentre study involving neurology practices (n = 30) and pain departments (n = 8) was conducted to assess the prevalence o...

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Bibliographic Details
Published in:European journal of pain 2013-11, Vol.17 (10), p.1547-1557
Main Authors: Radat, F., Margot-Duclot, A., Attal, N.
Format: Article
Language:English
Subjects:
Adult
Aged
Anxiety Disorders - epidemiology
Anxiety Disorders - therapy
Chronic Pain - epidemiology
Chronic Pain - therapy
Cohort Studies
Comorbidity
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - therapy
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Male
Middle Aged
Neuralgia - epidemiology
Neuralgia - therapy
Pain Measurement
Psychiatric Status Rating Scales
Treatment Outcome
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Summary:Background Psychiatric co‐morbidities are common in patients with chronic pain, but no data are available about their prevalence in patients with neuropathic pain. Methods A multicentre study involving neurology practices (n = 30) and pain departments (n = 8) was conducted to assess the prevalence of lifetime and current anxiety and mood disorders on the basis of DSM‐IV criteria in patients with peripheral neuropathic pain. Factors independently associated with such co‐morbidity were also studied. A total of 182 consecutive patients (age 59.5 ± 13.8 years, 48% men) were recruited. Assessments included lifetime and current anxiety and mood disorders (Mini International Neuropsychiatric Interview), sleep (Medical Outcome Study sleep scale), pain interference (Brief Pain Inventory) and catastrophizing (Pain Catastrophizing Scale). Results Lifetime and current prevalence of psychiatric co‐morbidity were 39% and 20.3%, respectively, for any anxiety disorder, and 47.2% and 29.7%, respectively, for any mood disorder. The two most common psychiatric disorders were generalized anxiety (current prevalence 12.1%) and major depressive episode (current prevalence: 16.5%). Logistic regression analyses showed that high catastrophizing was the most significant variable independently associated with both current anxiety (OR = 4.21[1.4–12.7]; p = 0.04) and mood disorders (OR = 6.9[2.2–21]; p 
ISSN:1090-3801
1532-2149
DOI:10.1002/j.1532-2149.2013.00334.x