Thrombophilia differences in splanchnic vein thrombosis and lower extremity deep venous thrombosis in North America

Background The utility of thrombophilia testing in patients with splanchnic vein thrombosis (SpVT) has not previously been rigorously evaluated. The purpose of this study was to characterize differences in the prevalence of thrombophilia in patients with SpVT involving portal (PVT), mesenteric (MVT)...

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Bibliographic Details
Published in:Journal of gastroenterology 2013-10, Vol.48 (10), p.1111-1118
Main Authors: Sutkowska, Edyta, McBane, Robert D., Tafur, Alfonso J., Sutkowski, Krzysztof, Grill, Diane E., Slusser, Joshua P., Wysokinski, Waldemar E.
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Anticoagulants (Medicine)
Blood Coagulation
Colorectal Surgery
Female
Gastroenterology
Hepatology
Humans
Lower Extremity
Male
Medicine
Medicine & Public Health
Middle Aged
North America - epidemiology
Original Article—Alimentary Tract
Prevalence
Splanchnic Circulation
Surgical Oncology
Thrombophilia - epidemiology
Venous Thrombosis - epidemiology
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Summary:Background The utility of thrombophilia testing in patients with splanchnic vein thrombosis (SpVT) has not previously been rigorously evaluated. The purpose of this study was to characterize differences in the prevalence of thrombophilia in patients with SpVT involving portal (PVT), mesenteric (MVT), splenic (SVT), or hepatic (HVT) veins in isolation or with multisegmental (M-SpVT) involvement compared to patients with lower extremity deep vein thrombosis (DVT). Methods An inception cohort of patients with incident SpVT was identified for whom comprehensive thrombophilia testing was performed between 1995 and 2005 and compared to DVT controls. Results 341 patients with SpVT (mean age 50 ± 16 years, 53 % women) including isolated PVT ( n  = 112), MVT ( n  = 67), HVT ( n  = 22), SVT ( n  = 11), and M-SpVT ( n  = 129) involvement and 3621 DVT controls (mean age 55 ± 16 years, 56 % women) had comprehensive thrombophilia testing. The prevalence of abnormal results was similar for SpVT (24.6 %) and DVT (25.9 %) patients. “Strong” thrombophilias were more prevalent among SpVT patients (12.3 vs. 8.5 %, p  = 0.0168). Patients with splenic (45.5 %) and mesenteric (41.8 %) thrombosis had the highest thrombophilia prevalence. Protein S deficiency was more common in SpVT patients (3.5 vs. 0.9 %, p  
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-012-0728-3