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New Pterosin Sesquiterpenes and Antitubercular Constituents from Pteris ensiformis

Two new pterosin sesquiterpenes, (2S)‐13‐hydroxypterosin A (1) and (2S,3S)‐12‐hydroxypterosin Q (2), were isolated from the whole plants of Pteris ensiformis, together with six known compounds. The structures of 1 and 2 were determined through extensive 1D/2D‐NMR and MS analyses. Compound 2 exhibite...

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Published in:	Chemistry & biodiversity 2013-10, Vol.10 (10), p.1903-1908
Main Authors:	Chen, Jih-Jung, Wang, Tai-Chi, Yang, Chieh-Kai, Liao, Hsiang-Ruei, Sung, Ping-Jyun, Chen, Ih-Sheng, Cheng, Ming-Jen, Peng, Chien-Fang, Chen, Jinn-Fen
Format:	Article
Language:	English
Subjects:	Antitubercular activity Antitubercular Agents - chemistry Antitubercular Agents - isolation & purification Antitubercular Agents - pharmacology Indans - chemistry Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Conformation Mycobacterium tuberculosis - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology Pteris - chemistry Pteris - metabolism Pteris ensiformis Pterosin sesquiterpenes Sesquiterpenes Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
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description	Two new pterosin sesquiterpenes, (2S)‐13‐hydroxypterosin A (1) and (2S,3S)‐12‐hydroxypterosin Q (2), were isolated from the whole plants of Pteris ensiformis, together with six known compounds. The structures of 1 and 2 were determined through extensive 1D/2D‐NMR and MS analyses. Compound 2 exhibited antitubercular activity (MIC 6.25 μg/ml) against Mycobacterium tuberculosis H37Rv in vitro.
doi_str_mv	10.1002/cbdv.201300072
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subjects	Antitubercular activity Antitubercular Agents - chemistry Antitubercular Agents - isolation & purification Antitubercular Agents - pharmacology Indans - chemistry Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Conformation Mycobacterium tuberculosis - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology Pteris - chemistry Pteris - metabolism Pteris ensiformis Pterosin sesquiterpenes Sesquiterpenes Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
title	New Pterosin Sesquiterpenes and Antitubercular Constituents from Pteris ensiformis
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