Albumin concentration determined by the modified bromocresol purple method is superior to that by the bromocresol green method for assessing nutritional status in malnourished patients with inflammation

Background The controlling nutritional status (CONUT) score (CS), a simple score for assessing nutritional status, is calculated using laboratory data, including serum albumin concentration. Although dye-binding assays such as the bromocresol green (BCG) and modified bromocresol purple (mBCP) method...

Full description

Saved in:
Bibliographic Details
Published in:Annals of clinical biochemistry 2013-11, Vol.50 (6), p.576-584
Main Authors: Ueno, Tsuyoshi, Hirayama, Satoshi, Ito, Masayuki, Nishioka, Emiko, Fukushima, Yoshifumi, Satoh, Tomoaki, Idei, Mayumi, Horiuchi, Yuki, Shoji, Hiromichi, Ohmura, Hirotoshi, Shimizu, Toshiaki, Miida, Takashi
Format: Article
Language:English
Subjects:
Aged
Blood Chemical Analysis - methods
Bromcresol Green - analysis
Bromcresol Green - chemistry
Bromcresol Purple - analysis
Bromcresol Purple - chemistry
Female
Haptoglobins - pharmacology
Humans
Inflammation - complications
Male
Malnutrition - blood
Malnutrition - complications
Malnutrition - physiopathology
Middle Aged
Nutritional Status
Serum Albumin - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The controlling nutritional status (CONUT) score (CS), a simple score for assessing nutritional status, is calculated using laboratory data, including serum albumin concentration. Although dye-binding assays such as the bromocresol green (BCG) and modified bromocresol purple (mBCP) methods are widely used for albumin measurement, acute-phase proteins interfere with the BCG method. Objective We aimed to determine whether the choice of albumin assay affects assessment of nutritional status using CONUT scores (CSs). Design We measured serum albumin concentrations by the BCG (ALBBCG) and mBCP (ALBmBCP) methods in 44 malnourished inpatients, 27 of whom underwent nutritional intervention, and compared them to 30 age-matched healthy volunteers. In treated patients, CSs were calculated by ALBBCG (CS-BCG) and ALBmBCP (CS-mBCP). Results C-reactive protein (CRP) concentrations were positively correlated with the difference between ALBBCG and ALBmBCP in malnourished inpatients (r = 0.59, p 
ISSN:0004-5632
1758-1001
DOI:10.1177/0004563213480137