Anemia and type 2 diabetes mellitus associated with peripheral arterial disease progression in Chinese male patients

• Published in: Clinical biochemistry 2013-11, Vol.46 (16-17), p.1673-1677
• Main Authors: Dang, Yiping, Xia, Yin, Li, Yiqing, Yu, Danny C.W.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Anemia - complications; Anemia and type 2 diabetes mellitus; Arteriosclerosis obliterans; Asian Continental Ancestry Group; China; Demography; Diabetes Mellitus, Type 2 - complications; Disease Progression; Female; Hemoglobins - metabolism; Humans; Male; Middle Aged; Peripheral arterial disease; Peripheral Arterial Disease - complications; Peripheral Arterial Disease - pathology; Statistics, Nonparametric
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2013.07.016

Peripheral arterial disease (PAD) is a chronic occlusive disease mainly occurred in elderly adults. Arteriosclerosis obliterans (ASO) mainly occurring from small or medium sized arteries of the lower extremities is one of the most common causes of PAD. The gender-related differences of circulating risk factors in diabetic patients with ASO in China remain unknown. The aim of this study is to investigate the gender-related differences in the pattern of several potential risk factors between male and female patients with ASO and type 2 diabetes mellitus (T2D). Clinical profiles and risk factors were analyzed in 323 Chinese patients with ASO and 112 patients were confirmed with T2D. Severities of limb ischemia were staged according to Fontaine classification. The significant inverse correlation was seen between the increased age and hemoglobin. The significant positive correlation was seen between the increased age, urea and creatinine both in the non-diabetic and diabetic male patients. The expression levels of hemoglobin significantly correlate with the classification of Fontaine clinical symptoms in Chinese male patients with T2D/ASO. The study is the first report indicating that the gender-related differences of circulating risk factors are associated with T2D patients with ASO in China. Anemia in Chinese male patients with T2D/ASO may play an important role in peripheral arterial disease progression. •Arteriosclerosis obliterans (ASO) mainly occurring from small or medium sized arteries of the lower extremities is one of the most common causes of peripheral arterial disease (PAD).•This study is the first report indicating that gender-related differences of circulating risk factors including urea, creatinine, uric acid and hemoglobin are significant related with increased age in Chinese ASO patients with type 2 diabetes mellitus (T2D).•Chinese male patients with anemia and T2D had significant association with peripheral arterial disease progression.